Contrasting effects of mitogenic growth factors on oligodendrocyte precursor cell migration

Milner, Richard, Anderson, Helen J., Rippon, Rebecca F., Mckay, Jennifer S., Franklin, Robin J.M., Marchionni, Mark A., Reynolds, Richard and Ffrench-Constant, Charles ORCID: https://orcid.org/0000-0002-5621-3377 (1998) Contrasting effects of mitogenic growth factors on oligodendrocyte precursor cell migration. Glia, 19 (1). pp. 85-90. ISSN 0894-1491

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Abstract

We have examined the effects of the mitogenic growth factors platelet derived growth factor (PDGF), basic fibroblast growth factor (bFGF) and glial growth factor-2 (GGF-2) on oligodendrocyte precursor migration. In an agarose drop migration assay PDGF and bFGF stimulated migration while GGF-2 had no effect. The migration-enhancing effect of bFGF cannot be blocked by neutralising antibodies against PDGF, confirming that this effect is direct and not mediated via upregulation of PDGF receptors. Based on our results, we propose a model in which the differing effects of PDGF and GGF-2 ensure appropriate numbers of oligodendrocyte precursor cells in the vicinity of axons to be myelinated during development.

Item Type: Article
Uncontrolled Keywords: basic fibroblast growth factor (bfgf),glial growth factor-2 (ggf-2),myelination,neuregulin,platelet derived growth factor (pdgf),proliferation,neurology,cellular and molecular neuroscience ,/dk/atira/pure/subjectarea/asjc/2800/2808
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 16 Jul 2022 16:30
Last Modified: 13 Aug 2022 02:22
URI: https://ueaeprints.uea.ac.uk/id/eprint/86379
DOI: 10.1002/(SICI)1098-1136(199701)19:1<85::AID-GLIA9>3.0.CO;2-9

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