Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington's disease gene carriers

Berrios, German E., Wagle, A. C., Marková, Ivana S., Wagle, S. A., Ho, Luk W., Rubinsztein, David C., Whittaker, Joanne, Ffrench-Constant, Charles ORCID:, Kershaw, Ann, Rosser, Anne, Bak, Thomas and Hodges, John R. (2001) Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington's disease gene carriers. Psychiatry Research, 102 (3). pp. 217-225. ISSN 0165-1781

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The putative relationship between the psychiatric profile of a sample of neurologically asymptomatic Huntington's disease gene carriers and CAG repeats was investigated. The psychiatric assessments (by consultant psychiatrist and computerised battery) were undertaken before the genetic testing was carried out. In this way, the informational distortions caused by neurological and cognitive deficits were avoided. The hypothesis that there is a relationship between psychiatric and CAG repeats was tested by seeking direct correlations between psychiatric systoms and CAG repeats, and also by correcting the correlation by the number of years above or below the estimated age of onset in Huntington's disease. Scores for irritability and cognitive failures were high in the sample. There was no correlation between any psychiatric variable and CAG repeats. Possible explanations for this lack of correlations are discussed.

Item Type: Article
Uncontrolled Keywords: age of onset,cognition,genetics,irritability,psychiatry and mental health,biological psychiatry,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2738
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science
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Depositing User: LivePure Connector
Date Deposited: 16 Jul 2022 13:30
Last Modified: 23 Oct 2022 03:57
DOI: 10.1016/S0165-1781(01)00257-8

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