Mechanisms of glial development

Colognato, Holly and Ffrench-Constant, Charles ORCID: https://orcid.org/0000-0002-5621-3377 (2004) Mechanisms of glial development. Current Opinion in Neurobiology, 14 (1). pp. 37-44. ISSN 0959-4388

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Abstract

Glial cells comprise most of the non-neuronal cells of the brain and peripheral nervous system, and include the myelin-forming oligodendrocytes and Schwann cells, radial glia and astrocytes. Their functions are diverse and include almost every aspect of nervous system function, from the birth and death of cells to the migrations and cell-cell interactions that connect and integrate the working elements of the nervous system. Recent studies have provided exciting insights into the mechanisms that drive the conversion into a glial cell and the developmental signals that guide the behavior of these multifunctional cells. An emerging theme is the so-called glial lineage being more diverse and more plastic than was previously thought. Here, we highlight some recent insights into glial development.

Item Type: Article
Additional Information: Funding Information: H Colognato is funded by a National Multiple Sclerosis Society Career Transition Fellowship, and C ffrench-Constant is funded by a Wellcome Trust Research leave fellowship for clinical academics.
Uncontrolled Keywords: 2′,3′-cyclic nucleotide 3′-phosphosdiesterase,basic helix-loop-helix,bhlh,bmp,bone morphogen protein,cnp,erm,family of proteins composed of ezrin, radixin and moesin,gdnf,glial-derived neurotrophic factor,ha,histone deacetylase,ncam,neuroscience(all) ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 16 Jul 2022 12:30
Last Modified: 17 Jul 2022 00:29
URI: https://ueaeprints.uea.ac.uk/id/eprint/86342
DOI: 10.1016/j.conb.2004.01.009

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