Integrins:Versatile integrators of extracellular signals

Ffrench-Constant, Charles ORCID: and Colognato, Holly (2004) Integrins:Versatile integrators of extracellular signals. Trends in Cell Biology, 14 (12). pp. 678-686. ISSN 0962-8924

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Extracellular matrix (ECM) molecules and growth factors have a crucial role in the signalling that controls cell behaviour during development. Integrins, which are cell-surface receptors for ECM molecules, and growth factor receptors cooperate with each other to regulate this signalling by several mechanisms. In particular, direct interactions between the integrin and growth factor receptors themselves, which often occur within a single macromolecular complex, amplify signalling by mechanisms that include posttranslational modifications and integrin shape changes that are related to activation. As a result, growth factor concentrations in the physiological range, which are too low to initiate signalling alone, do so in the presence of the ECM, enabling integrins to control the time and space of growth factor signalling.

Item Type: Article
Additional Information: Funding Information: We are funded by grants from the Wellcome Trust and the Multiple Sclerosis Society of Great Britain and Northern Ireland (to C.ff-C.), and by a National Multiple Sclerosis Society Career Transition fellowship that follows on from a National Institutes of Health postdoctoral fellowship (to H.C.). We are grateful to the anonymous referees of the manuscript for their helpful comments.
Uncontrolled Keywords: cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1307
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 16 Jul 2022 11:31
Last Modified: 23 Oct 2022 03:57
DOI: 10.1016/j.tcb.2004.10.005

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