Human diseases reveal novel roles for neural laminins

Colognato, Holly, Ffrench-Constant, Charles ORCID: https://orcid.org/0000-0002-5621-3377 and Feltri, Maria Laura (2005) Human diseases reveal novel roles for neural laminins. Trends in Neurosciences, 28 (9). pp. 480-486. ISSN 0166-2236

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Abstract

Extracellular matrix molecules such as laminins have a central role in regulating cell behaviour. However, our understanding of their functions in the mammalian nervous system is incomplete. It is important to establish these functions, both for an understanding of normal development and to devise strategies to enhance repair. Here, we review how insights gained from human diseases caused by genetic mutations in laminins or their receptors have revealed significant and sometimes unexpected roles for laminins in neural stem cells, migrating neurons and myelinating glia, in both the PNS and CNS.

Item Type: Article
Additional Information: Funding Information: Work in our laboratories is funded by a Career Transition Fellowship from the National Multiple Sclerosis Society (H.C.), the Wellcome Trust and the FP5 programme of the EU (C.ff-C.), and the NIH (R01-NS045630) and Telethon, Italy (M.L.F.).
Uncontrolled Keywords: neuroscience(all),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 16 Jul 2022 11:31
Last Modified: 18 Jul 2022 00:28
URI: https://ueaeprints.uea.ac.uk/id/eprint/86329
DOI: 10.1016/j.tins.2005.07.004

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