β1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination

Benninger, Yves, Colognato, Holly, Thurnherr, Tina, Franklin, Robin J.M., Leone, Dino P., Atanasoski, Suzana, Nave, Klaus Armin, Ffrench-Constant, Charles ORCID: https://orcid.org/0000-0002-5621-3377, Suter, Ueli and Relvas, João B. (2006) β1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination. Journal of Neuroscience, 26 (29). pp. 7665-7673. ISSN 0270-6474

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Abstract

Previous reports, including transplantation experiments using dominant-negative inhibition of β1-integrin signaling in oligodendrocyte progenitor cells, suggested that β1-integrin signaling is required for myelination. Here, we test this hypothesis using conditional ablation of the β1-integrin gene in oligodendroglial cells during the development of the CNS. This approach allowed us to study oligodendroglial β1-integrin signaling in the physiological environment of the CNS, circumventing the potential drawbacks of a dominant-negative approach. We found that β1-integrin signaling has a much more limited role than previously expected. Although it was involved in stage-specific oligodendrocyte cell survival, β1-integrin signaling was not required for axon ensheathment and myelination per se. We also found that, in the spinal cord, remyelination occurred normally in the absence of β1-integrin. We conclude that, although β1-integrin may still contribute to other aspects of oligodendrocyte biology, it is not essential for myelination and remyelination in the CNS.

Item Type: Article
Uncontrolled Keywords: cns,integrins,myelin,oligodendrocytes,remyelination,survival,neuroscience(all) ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 16 Jul 2022 11:31
Last Modified: 18 Sep 2022 04:12
URI: https://ueaeprints.uea.ac.uk/id/eprint/86323
DOI: 10.1523/JNEUROSCI.0444-06.2006

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