Patterns of laminins and integrins in the embryonic ventricular zone of the CNS

Lathia, Justin D., Patton, Bruce, Eckley, D. Mark, Magnus, Tim, Mughal, Mohamed R., Sasaki, Takako, Caldwell, Maeve A., Rao, Mahendra S., Mattson, Mark P. and Ffrench-Constant, Charles ORCID: (2007) Patterns of laminins and integrins in the embryonic ventricular zone of the CNS. Journal of Comparative Neurology, 505 (6). pp. 630-643. ISSN 0021-9967

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The extracellular matrix (ECM) provides both a physical framework and a microenvironment that supplies instructive signals from the earliest stages of multicellular development. As a first step toward understanding the role of the ECM in regulating the behavior of neural stem cells (NSCs), here we show the localization of laminins, a heterotrimeric family of ECM molecules expressed in many different stem cell microenvironments, and their corresponding receptors in the embryonic murine ventricular zone (VZ) within which the NSCs undergo symmetrical and asymmetrical divisions required for cortical development. In addition to the presence of laminins containing both the α2 and α4 chains, we find distinct patterns of ECM receptor expression in the VZ and in the overlying cortex. Neural stem cells derived from the VZ express high levels of the integrin laminin receptor α6β1. At developmental stages at which NSCs undergo asymmetrical divisions, integrin β1 was unevenly distributed in some mitotic pairs at the ventricular wall. These results suggest a significant role in the regulation of NSC fate for laminin/integrin signaling within the microenvironment of the VZ and provide a framework for future molecular and cellular analyses of the role of the ECM in neural development.

Item Type: Article
Uncontrolled Keywords: dystroglycan,extracellular matrix,integrin,laminin,neural stem cell,neurogenesis,radial glia,stem cell niche,syndecan,neuroscience(all) ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 16 Jul 2022 11:31
Last Modified: 22 Oct 2022 18:37
DOI: 10.1002/cne.21520

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