Adhesion molecules in the regulation of CNS myelination

Laursen, Lisbeth S. and Ffrench-Constant, Charles ORCID: https://orcid.org/0000-0002-5621-3377 (2008) Adhesion molecules in the regulation of CNS myelination. Neuron Glia Biology, 3 (4). pp. 367-375. ISSN 1740-925X

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Abstract

Myelination is necessary both for rapid salutatory conduction and the long-term survival of the axon. In the CNS the myelin sheath is formed by the oligodendrocytes. Each oligodendrocyte myelinates several axons and, as the number of wraps around each axon is determined precisely by the axon diameter, this requires a close, highly regulated interaction between the axons and each of the oligodendrocyte processes. Adhesion molecules are likely to play an important role in the bi-directional signalling between axon and oligodendrocyte that underlies this interaction. Here we review the current knowledge of the function of adhesion molecules in the different phases of oligodendrocyte differentiation and myelination, and discuss how the properties of these proteins defined by other cell biological systems indicates potential roles in oligodendrocytes. We show how the function of a number of different adhesion and cell-cell interaction molecules such as polysialic acid neural cell adhesion molecule, Lingo-1, Notch, neuregulin, integrins and extracellullar matrix proteins provide negative and positive signals that coordinate the formation of the myelin membrane. Compiling this information from a number of different cell biological and genetic experiments helps us to understand the pathology of multiple sclerosis and direct new areas of research that might eventually lead to potential drug targets to increase remyelination.

Item Type: Article
Additional Information: Funding Information: The authors wish to thank the ffrench-Constant lab and Prof. Robin Franklin (Cambridge) for helpful comments and discussions. The authors are supported by a postdoctoral fellowship from the Alfred Benzon foundation and the Danish Medical Research Council to LSL, and by grants from the Wellcome Trust, the UK Multiple Sclerosis Society and the National Multiple Sclerosis Society to Cff-C.
Uncontrolled Keywords: axon,integrin,laminin,multiple sclerosis,myelin,oligodendrocyte,cellular and molecular neuroscience,cell biology ,/dk/atira/pure/subjectarea/asjc/2800/2804
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 16 Jul 2022 11:30
Last Modified: 17 Jul 2022 00:27
URI: https://ueaeprints.uea.ac.uk/id/eprint/86313
DOI: 10.1017/S1740925X08000161

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