Role of the oligodendroglial cytoskeleton in differentiation and myelination

Bauer, Nina G., Richter-Landsberg, Christiane and ffrench-Constant, Charles ORCID: (2009) Role of the oligodendroglial cytoskeleton in differentiation and myelination. Glia, 57 (16). pp. 1691-1705. ISSN 0894-1491

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Oligodendrocytes, the myelin-forming cells of the central nervous system, are in culture characterized by an elaborate process network, terminating in flat membranous sheets that are rich in myelin-specific proteins and lipids, and spirally wrap axons forming a compact insulating layer in vivo. By analogy with other cell types, maintenance and stability of these processes, as well as the formation of the myelin sheath, likely rely on a pronounced cytoskeleton consisting of microtubules and microfilaments. While the specialized process of wrapping and compaction forming the myelin sheath is not well understood, considerably more is known about how cytoskeletal organization is mediated by extracellular and intracellular signals and other interaction partners during oligodendrocyte differentiation and myelination. Here, we review the current state of knowledge on the role of the oligodendrocyte cytoskeleton in differentiation with an emphasis on signal transduction mechanisms and will attempt to draw out implications for its significance in myelination.

Item Type: Article
Uncontrolled Keywords: extracellular matrix,microfilaments,microtubules,oligodendrocytes,signal transduction,neurology,cellular and molecular neuroscience ,/dk/atira/pure/subjectarea/asjc/2800/2808
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 16 Jul 2022 11:30
Last Modified: 13 Jul 2024 20:31
DOI: 10.1002/glia.20885

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