Adhesion molecules in the stem cell niche - More than just staying in shape?

Marthiens, Véronique, Kazanis, Ilias, Moss, Lara, Long, Katherine and Ffrench-Constant, Charles ORCID: (2010) Adhesion molecules in the stem cell niche - More than just staying in shape? Journal of Cell Science, 123 (10). pp. 1613-1622. ISSN 0021-9533

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The expression of adhesion molecules by stem cells within their niches is well described, but what is their function? A conventional view is that these adhesion molecules simply retain stem cells in the niche and thereby maintain its architecture and shape. Here, we review recent literature showing that this is but one of their roles, and that they have essential functions in all aspects of the stem cell-niche interaction - retention, division and exit. We also highlight from this literature evidence supporting a simple model whereby the regulation of centrosome positioning and spindle angle is regulated by both cadherins and integrins, and the differential activity of these two adhesion molecules enables the fundamental stem cell property of switching between asymmetrical and symmetrical divisions.

Item Type: Article
Uncontrolled Keywords: adherens junction,basal lamina,cadherin,centrosome,integrin,stem cell niche,cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1307
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 16 Jul 2022 11:30
Last Modified: 23 Oct 2022 03:57
DOI: 10.1242/jcs.054312

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