Myelin Regeneration in Multiple Sclerosis:Targeting Endogenous Stem Cells

Huang, Jeffrey K., Fancy, Stephen P.J., Zhao, Chao, Rowitch, David H., ffrench-Constant, Charles ORCID: https://orcid.org/0000-0002-5621-3377 and Franklin, Robin J.M. (2011) Myelin Regeneration in Multiple Sclerosis:Targeting Endogenous Stem Cells. Neurotherapeutics, 8 (4). pp. 650-658. ISSN 1933-7213

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Abstract

Regeneration of myelin sheaths (remyelination) after central nervous system demyelination is important to restore saltatory conduction and to prevent axonal loss. In multiple sclerosis, the insufficiency of remyelination leads to the irreversible degeneration of axons and correlated clinical decline. Therefore, a regenerative strategy to encourage remyelination may protect axons and improve symptoms in multiple sclerosis. We highlight recent studies on factors that influence endogenous remyelination and potential promising pharmacological targets that may be considered for enhancing central nervous system remyelination.

Item Type: Article
Uncontrolled Keywords: multiple sclerosis,regenerative medicine,remyelination,stem cell,pharmacology,clinical neurology,pharmacology (medical) ,/dk/atira/pure/subjectarea/asjc/3000/3004
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 16 Jul 2022 00:27
Last Modified: 12 Aug 2022 05:39
URI: https://ueaeprints.uea.ac.uk/id/eprint/86284
DOI: 10.1007/s13311-011-0065-x

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