The number of stem cells in the subependymal zone of the adult rodent brain is correlated with the number of ependymal cells and not with the volume of the niche

Kazanis, Ilias and Ffrench-Constant, Charles ORCID: https://orcid.org/0000-0002-5621-3377 (2011) The number of stem cells in the subependymal zone of the adult rodent brain is correlated with the number of ependymal cells and not with the volume of the niche. Stem Cells and Development, 21 (7). pp. 1090-1096. ISSN 1547-3287

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Abstract

The mammalian subependymal zone (SEZ; often called subventricular) situated at the lateral walls of the lateral ventricles of the brain contains a pool of relatively quiescent adult neural stem cells whose neurogenic activity persists throughout life. These stem cells are positioned in close proximity both to the ependymal cells that provide the cerebrospinal fluid interface and to the blood vessel endothelial cells, but the relative contribution of these 2 cell types to stem cell regulation remains undetermined. Here, we address this question by analyzing a naturally occurring example of volumetric scaling of the SEZ in a comparison of the mouse SEZ with the larger rat SEZ. Our analysis reveals that the number of stem cells in the SEZ niche is correlated with the number of ependymal cells rather than with the volume, thereby indicating the importance of ependymal-derived factors in the formation and function of the SEZ. The elucidation of the factors generated by ependymal cells that regulate stem cell numbers within the SEZ is, therefore, of importance for stem cell biology and regenerative neuroscience.

Item Type: Article
Uncontrolled Keywords: hematology,developmental biology,cell biology ,/dk/atira/pure/subjectarea/asjc/2700/2720
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 16 Jul 2022 00:27
Last Modified: 12 Aug 2022 05:39
URI: https://ueaeprints.uea.ac.uk/id/eprint/86279
DOI: 10.1089/scd.2011.0130

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