De La Fuente, Alerie Guzman, Errea, Oihana, Van Wijngaarden, Peter, Gonzalez, Ginez A., Kerninon, Christophe, Jarjour, Andrew A., Lewis, Hilary J., Jones, Clare A., Nait-Oumesmar, Brahim, Zhao, Chao, Huang, Jeffrey K., Ffrench-Constant, Charles ORCID: https://orcid.org/0000-0002-5621-3377 and Franklin, Robin J.M. (2015) Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation. Journal of Cell Biology, 211 (5). pp. 975-985. ISSN 0021-9525

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Abstract

The mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor cells (OPCs) into mature OLGs are key to understanding myelination and remyelination. Signaling via the retinoid X receptor γ (RXR-γ) has been shown to be a positive regulator of OPC differentiation. However, the nuclear receptor (NR) binding partner of RXR-γ has not been established. In this study we show that RXR-γ binds to several NRs in OPCs and OLGs, one of which is vitamin D receptor (VDR). Using pharmacological and knockdown approaches we show that RXR-VDR signaling induces OPC differentiation and that VDR agonist vitamin D enhances OPC differentiation. We also show expression of VDR in OLG lineage cells in multiple sclerosis. Our data reveal a role for vitamin D in the regenerative component of demyelinating disease and identify a new target for remyelination medicines.

Item Type:	Article
Uncontrolled Keywords:	cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1307
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	15 Jul 2022 22:30
Last Modified:	12 Aug 2022 05:38
URI:	https://ueaeprints.uea.ac.uk/id/eprint/86254
DOI:	10.1083/jcb.201505119

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