Regulation of the neural stem cell compartment by extracellular matrix constituents

Theocharidis, Ursula, Long, Katherine, ffrench-Constant, Charles ORCID: and Faissner, Andreas (2014) Regulation of the neural stem cell compartment by extracellular matrix constituents. In: Progress in Brain Research. Progress in Brain Research . Elsevier, pp. 3-28.

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Neural stem cells (NSCs) derive from the neuroepithelium of the neural tube, develop into radial glial cells, and recede at later developmental stages. In the adult, late descendants of these embryonic NSCs reside in discretely confined areas of the central nervous system, the stem cell niches. The best accepted canonical niches are the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus of the hippocampus. Stem cell niches provide a privileged environment to NSCs that supports self-renewal and maintenance of this cellular compartment. While numerous studies have highlighted the importance of transcription factors, morphogens, cytokines, and growth factors as intrinsic and extrinsic factors of stem cell regulation, less attention has been paid to the molecular micromilieu that characterizes the stem cell niches. In this chapter, we summarize increasing evidence that the extracellular matrix (ECM) of the stem cell environment is of crucial importance for the biology of this cellular compartment. A deeper understanding of the molecular composition of the ECM, the complementary receptors, and the signal transduction pathways engaged may prove highly relevant for harnessing NSCs in the context of biotechnological applications.

Item Type: Book Section
Additional Information: Funding Information: We acknowledge grant support by the Stem Cell Network North Rhine Westphalia, the German Research Foundation (DFG: SPP 1109, Fa 159/16-1, GRK 736, and GSC 98/1), the German Ministry of Education, Research and Technology (BMBF 01GN0503), and the Ruhr University (President's special programme call 2008). We are thankful to Dr. T. Czopka for the generation of tenascin-C riboprobes and Melina Terhufen and Nina Kornblum for the experimental procedures.
Uncontrolled Keywords: asymmetrical division,extracellular matrix,glial progenitors,integrins,laminin,neural stem cell niche,phosphacan,proteoglycans,radial glial cells,subventricular zone,tenascin,neuroscience(all) ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 15 Jul 2022 22:30
Last Modified: 22 Oct 2022 23:57
DOI: 10.1016/B978-0-444-63486-3.00001-3

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