Extracellular matrix regulation of stem cell behavior

Ahmed, Maqsood and ffrench-Constant, Charles ORCID: https://orcid.org/0000-0002-5621-3377 (2016) Extracellular matrix regulation of stem cell behavior. Current Stem Cell Reports, 2 (3). pp. 197-206. ISSN 2198-7866

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Stem cells hold great promise in treating many diseases either through promoting endogenous cell repair or through direct cell transplants. In order to maximize their potential, understanding the fundamental signals and mechanisms that regulate their behavior is essential. The extracellular matrix (ECM) is one such component involved in mediating stem cell fate. Recent studies have made significant progress in understanding stem cell-ECM interactions. Technological developments have provided greater clarity in how cells may sense and respond to the ECM, in particular the physical properties of the matrix. This review summarizes recent developments, providing illustrative examples of the different modes with which the ECM controls both embryonic and adult stem cell behavior.

Item Type: Article
Uncontrolled Keywords: extracellular matrix,microenvironment,regeneration,stem cell niche,stem cells,molecular biology,genetics,developmental biology,cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1312
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 15 Jul 2022 14:31
Last Modified: 29 Jun 2023 15:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/86241
DOI: 10.1007/s40778-016-0056-2


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