Regenerating CNS myelin - From mechanisms to experimental medicines

Franklin, Robin J.M. and Ffrench-Constant, Charles ORCID: (2017) Regenerating CNS myelin - From mechanisms to experimental medicines. Nature Reviews Neuroscience, 18 (12). pp. 753-769. ISSN 1471-003X

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Although the core concept of remyelination - based on the activation, migration, proliferation and differentiation of CNS progenitors - has not changed over the past 20 years, our understanding of the detailed mechanisms that underlie this process has developed considerably. We can now decorate the central events of remyelination with a host of pathways, molecules, mediators and cells, revealing a complex and precisely orchestrated process. These advances have led to recent drug-based and cell-based clinical trials for myelin diseases and have opened up hitherto unrecognized opportunities for drug-based approaches to therapeutically enhance remyelination.

Item Type: Article
Uncontrolled Keywords: neuroscience(all) ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 15 Jul 2022 14:31
Last Modified: 23 Oct 2022 03:56
DOI: 10.1038/nrn.2017.136

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