Intrinsic and adaptive myelination—A sequential mechanism for smart wiring in the brain

Bechler, Marie E., Swire, Matthew and ffrench-Constant, Charles ORCID: (2018) Intrinsic and adaptive myelination—A sequential mechanism for smart wiring in the brain. Developmental Neurobiology, 78 (2). pp. 68-79. ISSN 1932-8451

Full text not available from this repository. (Request a copy)


The concept of adaptive myelination—myelin plasticity regulated by activity—is an important advance for the field. What signals set up the adaptable pattern in the first place? Here we review work that demonstrates an intrinsic pathway within oligodendrocytes requiring only an axon-shaped substrate to generate multilayered and compacted myelin sheaths of a physiological length. Based on this, we discuss a model we proposed in 2015 which argues that myelination has two phases—intrinsic and then adaptive—which together generate “smart wiring,” in which active axons become more myelinated. This model explains why prior studies have failed to identify a signal necessary for central nervous system myelination and argues that myelination, like synapses, might contribute to learning by the activity-dependent modification of an initially hard-wired pattern.

Item Type: Article
Additional Information: Funding Information: Correspondence to: M.E. Bechler ( uk) Contract grant sponsor: Wellcome Trust; contract grant number: 104783/Z/14/Z. © 2017 The Authors. Developmental Neurobiology Published by Wiley Periodicals, Inc. Published online 22 August 2017 in Wiley Online Library ( DOI 10.1002/dneu.22518 This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: activity-dependent,glia,myelin,oligodendrocyte,plasticity,developmental neuroscience,cellular and molecular neuroscience ,/dk/atira/pure/subjectarea/asjc/2800/2806
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 15 Jul 2022 14:31
Last Modified: 13 Jul 2024 20:30
DOI: 10.1002/dneu.22518

Actions (login required)

View Item View Item