Endothelin signalling mediates experience-dependent myelination in the CNS

Swire, Matthew, Kotelevtsev, Yuri, Webb, David J., Lyons, David A. and ffrench-Constant, Charles ORCID: https://orcid.org/0000-0002-5621-3377 (2019) Endothelin signalling mediates experience-dependent myelination in the CNS. eLife, 8. ISSN 2050-084X

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Experience and changes in neuronal activity can alter CNS myelination, but the signalling pathways responsible remain poorly understood. Here we define a pathway in which endothelin, signalling through the G protein-coupled receptor endothelin receptor B and PKC epsilon, regulates the number of myelin sheaths formed by individual oligodendrocytes in mouse and zebrafish. We show that this phenotype is also observed in the prefrontal cortex of mice following social isolation, and is associated with reduced expression of vascular endothelin. Additionally, we show that increasing endothelin signalling rescues this myelination defect caused by social isolation. Together, these results indicate that the vasculature responds to changes in neuronal activity associated with experience by regulating endothelin levels, which in turn affect the myelinating capacity of oligodendrocytes. This pathway may be employed to couple the metabolic support function of myelin to activity-dependent demand and also represents a novel mechanism for adaptive myelination.

Item Type: Article
Additional Information: Funding Information: This work was supported by a MS Society Research Grant PhD studentship. This work was supported by a MS Society Research Grant PhD studentship (Grant Reference 950), a Wellcome Trust Senior Investigator Award to CffC and a Wellcome Trust Senior Research Fellowship (102836/Z/13/Z) to DL.
Uncontrolled Keywords: neuroscience(all),biochemistry, genetics and molecular biology(all),immunology and microbiology(all) ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 15 Jul 2022 13:30
Last Modified: 04 Mar 2024 18:11
URI: https://ueaeprints.uea.ac.uk/id/eprint/86223
DOI: 10.7554/eLife.49493

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