Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice

Lopez-Tello, Jorge, Schofield, Zoe, Kiu, Raymond, Dalby, Matthew J., van Sinderen, Douwe, Le Gall, Gwenaelle ORCID: https://orcid.org/0000-0002-1379-2196, Sferruzzi-Perri, Amanda N. and Hall, Lindsay J. ORCID: https://orcid.org/0000-0001-8938-5709 (2022) Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice. Cellular and Molecular Life Sciences, 79 (7). ISSN 1420-682X

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Abstract

The gut microbiota plays a central role in regulating host metabolism. While substantial progress has been made in discerning how the microbiota influences host functions post birth and beyond, little is known about how key members of the maternal gut microbiota can influence feto-placental growth. Notably, in pregnant women, Bifidobacterium represents a key beneficial microbiota genus, with levels observed to increase across pregnancy. Here, using germ-free and specific-pathogen-free mice, we demonstrate that the bacterium Bifidobacterium breve UCC2003 modulates maternal body adaptations, placental structure and nutrient transporter capacity, with implications for fetal metabolism and growth. Maternal and placental metabolome were affected by maternal gut microbiota (i.e. acetate, formate and carnitine). Histological analysis of the placenta confirmed that Bifidobacterium modifies placental structure via changes in Igf2P0, Dlk1, Mapk1 and Mapk14 expression. Additionally, B. breve UCC2003, acting through Slc2a1 and Fatp1-4 transporters, was shown to restore fetal glycaemia and fetal growth in association with changes in the fetal hepatic transcriptome. Our work emphasizes the importance of the maternal gut microbiota on feto-placental development and sets a foundation for future research towards the use of probiotics during pregnancy.

Item Type: Article
Additional Information: Funding Information: JL-T currently holds a Sir Henry Wellcome Postdoctoral Fellowship (220456/Z/20/Z) and previously a Newton International Fellowship from the Royal Society (NF170988 / RG90199). LJH is supported by Wellcome Trust Investigator Awards (100974/C/13/Z and 220876/Z/20/Z); the Biotechnology and Biological Sciences Research Council (BBSRC), Institute Strategic Programme Gut Microbes and Health (BB/R012490/1), and its constituent projects BBS/E/F/000PR10353 and BBS/E/F/000PR10356. ANS-P is supported by a Lister Institute of Preventative Medicine Research Prize (RG93692).
Uncontrolled Keywords: pregnancy,metabolism,microbiota,fetus,bifidobacterium,insulin sensitivity,mouse placenta,fatty-acids,alters,cellular and molecular neuroscience,molecular medicine,molecular biology,cell biology,pharmacology ,/dk/atira/pure/subjectarea/asjc/2800/2804
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 11 Jul 2022 12:30
Last Modified: 18 Jul 2022 08:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/86055
DOI: 10.1007/s00018-022-04379-y

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