TGF-Β1 & PNPLA3 genetic variants and the risk of hepatic fibrosis and HCC in Egyptian patients with HCV-related liver cirrhosis

Nomair, Azhar Mohamed, Kandil, Lamia Said ORCID: https://orcid.org/0000-0002-5414-5403, Nomeir, Hanan Mohamed and Kandil, Noha Said (2021) TGF-Β1 & PNPLA3 genetic variants and the risk of hepatic fibrosis and HCC in Egyptian patients with HCV-related liver cirrhosis. Asian Pacific Journal of Cancer Prevention, 22 (10). pp. 3317-3326. ISSN 1513-7368

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Abstract

Objective: The clinical outcomes of hepatitis C virus (HCV) infection and its sequelae including liver cirrhosis and hepatocellular carcinoma (HCC) are greatly affected by host genetic factors; however, the possible mechanisms are still largely unclear. This work aimed to assess transforming growth factor-β1 (TGF-β1), and patatin-like phospholipase domain containing-protein 3 (PNPLA3) genetic variants as risk factors for hepatic fibrosis and hepatocellular carcinoma (HCC) in Egyptian patients with HCV-related liver cirrhosis. Methods: Seventy HCV-related liver cirrhosis patients (Total cirrhosis) who were divided into two groups; 34 patients with HCC (HCC group), and 36 patients without HCC (LC group) and 20 healthy volunteers (control group) were included. Routine laboratory investigations and imaging studies were determined. TGF-β1 (Arg25Pro; 915G>C) and PNPLA3 (I148M; C>G) variants were evaluated using real-time polymerase chain reaction (real-time PCR). Results: HCC group showed a significantly higher GG genotype distribution of TGF-β1 (Arg25Pro) than the LC group (P= 0.008, OR: 7.083, CI 95%: 1.422 – 35.282). The distributions of GG genotype (P= 0.047) and G allele (P= 0.002, OR: 4.395, CI 95%: 1.622 – 11.911) of PNPLA3 (I148M) were significantly higher in total cirrhosis patients than controls. Conclusion: TGF-β1 (Arg25Pro) GG variant may be associated with HCC risk in HCV-related liver cirrhosis patients, while PNPLA3 (I148M) GG variant may be associated with cirrhosis development but not HCC risk in HCV-related liver cirrhosis patients.

Item Type: Article
Uncontrolled Keywords: gene polymorphism-liver fibrosis-hcc-hcv,epidemiology,oncology,public health, environmental and occupational health,cancer research ,/dk/atira/pure/subjectarea/asjc/2700/2713
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 06 Jul 2022 08:30
Last Modified: 14 Jul 2022 14:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/85977
DOI: 10.31557/APJCP.2021.22.10.3317

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