Improved antiparasitic activity by incorporation of organosilane entities into half-sandwich ruthenium(II) and rhodium(III) thiosemicarbazone complexes

Adams, Muneebah, de Kock, Carmen, Smith, Peter J., Land, Kirkwood M., Liu, Nicole, Hopper, Melissa, Hsiao, Allyson, Burgoyne, Andrew R., Stringer, Tameryn ORCID: https://orcid.org/0000-0002-4439-131X, Meyer, Mervin, Wiesner, Lubbe, Chibale, Kelly and Smith, Gregory S. (2015) Improved antiparasitic activity by incorporation of organosilane entities into half-sandwich ruthenium(II) and rhodium(III) thiosemicarbazone complexes. Dalton Transactions, 44 (5). pp. 2456-2468. ISSN 1477-9226

[img]
Preview
PDF (c4dt03234a) - Published Version
Available under License Creative Commons Attribution Non-commercial.

Download (823kB) | Preview

Abstract

A series of ferrocenyl- and aryl-functionalised organosilane thiosemicarbazone compounds was obtained via a nucleophilic substitution reaction with an amine-terminated organosilane. The thiosemicarbazone (TSC) ligands were further reacted with either a ruthenium dimer [(η6-iPrC6H4Me)Ru(μ-Cl)Cl]2 or a rhodium dimer [(Cp*)Rh(μ-Cl)Cl]2 to yield a series of cationic mono- and binuclear complexes. The thiosemicarbazone ligands, as well as their metal complexes, were characterised using NMR and IR spectroscopy, and mass spectrometry. The molecular structure of the binuclear ruthenium(II) complex was determined by single-crystal X-ray diffraction analysis. The thiosemicarbazones and their complexes were evaluated for their in vitro antiplasmodial activities against the chloroquine-sensitive (NF54) and chloroquine-resistant (Dd2) Plasmodium falciparum strains, displaying activities in the low micromolar range. Selected compounds were screened for potential β-haematin inhibition activity, and it was found that two Rh(III) complexes exhibited moderate to good inhibition. Furthermore, the compounds were screened for their antitrichomonal activities against the G3 Trichomonas vaginalis strain, revealing a higher percentage of growth inhibition for the ruthenium and rhodium complexes over their corresponding ligand.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 04 Jul 2022 09:30
Last Modified: 12 Aug 2022 05:32
URI: https://ueaeprints.uea.ac.uk/id/eprint/85910
DOI: 10.1039/c4dt03234a

Actions (login required)

View Item View Item