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Chellan, Prinessa, Stringer, Tameryn 
ORCID: https://orcid.org/0000-0002-4439-131X, Shokar, Ajit, Dornbush, Padraick J., Vazquez-Anaya, Guillermo, Land, Kirkwood M., Chibale, Kelly and Smith, Gregory S.
(2011)
Synthesis and in vitro evaluation of palladium(II) salicylaldiminato thiosemicarbazone complexes against Trichomonas vaginalis.
Journal of Inorganic Biochemistry, 105 (12).
pp. 1562-1568.
ISSN 0162-0134
Abstract
Eight mononuclear Pd(II) complexes containing salicylaldiminato thiosemicarbazones (saltsc-R; where R = H (1), 3-OMe (2), 3-tBu (3) and 5-Cl (4)) as dinegative tridentate ligands were prepared by the reaction of the corresponding thiosemicarbazone with the precursor Pd(L)2Cl2 (L = phosphatriazaadamantane or 4-picoline) in the presence of a weak base. These complexes (9–16) were characterised by a range of spectroscopic and analytical techniques including NMR spectroscopy and X-ray diffraction. These complexes along with four other Pd(II) analogues (5–8) were screened for activity in vitro against the Trichomonas vaginalis parasite. Preliminary results show that the type of ancillary ligand as well as the substituents on the aromatic ring of the salicylaldiminato thiosemicarbazone ligand influences the antiparasitic activity of these complexes.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Chemistry |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 04 Jul 2022 08:31 |
| Last Modified: | 23 Oct 2022 03:51 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/85903 |
| DOI: | 10.1016/j.jinorgbio.2011.07.023 |
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