Evaluating the effects of SARS-CoV-2 spike mutation D614G on transmissibility and pathogenicity

Colquhoun, Rachel M., da Silva Filipe, Ana, Shepherd, James, Pascall, David J., Shah, Rajiv, Jesudason, Natasha, Li, Kathy, Jarrett, Ruth, Pacchiarini, Nicole, Bull, Matthew, Geidelberg, Lily, Siveroni, Igor, , COG-UK Consortium, Goodfellow, Ian, Loman, Nicholas J., Pybus, Oliver G., Robertson, David L., Thomson, Emma C., Rambaut, Andrew and Connor, Thomas R. (2021) Evaluating the effects of SARS-CoV-2 spike mutation D614G on transmissibility and pathogenicity. Cell, 184 (1). 64-75.e11. ISSN 0092-8674

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Abstract

Analysis of the spread and frequency of SARS-CoV-2 D614G in the United Kingdom suggests a selective advantage for this strain that is associated with higher viral loads in younger patients but not higher COVID-19 clinical severity or mortality.

Item Type: Article
Additional Information: Funding Information: We thank all partners and contributors to the COG-UK consortium who are listed at https://www.cogconsortium.uk/about/ . We also acknowledge the important work of SARS-CoV-2 genome data producers globally contributing sequence data to the GISAID database and particularly acknowledge the groups who have generated data used by this project, listed in Table S4 . E.V. acknowledges the MRC Centre for Global Infectious Disease Analysis ( MR/R015600/1 ). R. Johnson and E.V. acknowledge funding from the European Commission (CoroNAb 101003653 ). V.H. was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) (grant no. BB/M010996/1 ). J.T.M., R.M.C., N.J.L., and A.R. acknowledge the support of the Wellcome Trust (Collaborators Award 206298/Z/17/Z – ARTIC network). A.R. is supported by the European Research Council (grant agreement no. 725422 – ReservoirDOCS). D.L.R., A.d.S.F., and E.C.T. are supported by the MRC ( MC_UU_1201412 ). J. Southgate was supported by the BBSRC -funded South West Biosciences Doctoral Training Partnership (training grant reference BB/M009122/1 ). T.R.C. and N.J.L. acknowledge support from the MRC , which funded computational resources used by the project (grant reference MR/L015080/1 ). T.R.C. acknowledges funding as part of the BBSRC Institute Strategic Programme Microbes in the Food Chain ( BB/R012504/1 ) and its constituent projects ( BBS/E/F/000PR10348 and BBS/E/F/000PR10352 ). A.P. and T.R.C. acknowledge support from Supercomputing Wales , which is partially funded by the European Regional Development Fund (ERDF) via Welsh Government . The project was also supported by specific funding from Welsh Government , which provided funds for the sequencing and analysis of a subset of the Welsh samples used in this study, via Genomics Partnership Wales. Funding Information: We thank all partners and contributors to the COG-UK consortium who are listed at https://www.cogconsortium.uk/about/. We also acknowledge the important work of SARS-CoV-2 genome data producers globally contributing sequence data to the GISAID database and particularly acknowledge the groups who have generated data used by this project, listed in Table S4. E.V. acknowledges the MRC Centre for Global Infectious Disease Analysis (MR/R015600/1). R. Johnson and E.V. acknowledge funding from the European Commission (CoroNAb 101003653). V.H. was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) (grant no. BB/M010996/1). J.T.M. R.M.C. N.J.L. and A.R. acknowledge the support of the Wellcome Trust (Collaborators Award 206298/Z/17/Z ? ARTIC network). A.R. is supported by the European Research Council (grant agreement no. 725422 ? ReservoirDOCS). D.L.R. A.d.S.F. and E.C.T. are supported by the MRC (MC_UU_1201412). J. Southgate was supported by the BBSRC-funded South West Biosciences Doctoral Training Partnership (training grant reference BB/M009122/1). T.R.C. and N.J.L. acknowledge support from the MRC, which funded computational resources used by the project (grant reference MR/L015080/1). T.R.C. acknowledges funding as part of the BBSRC Institute Strategic Programme Microbes in the Food Chain (BB/R012504/1) and its constituent projects (BBS/E/F/000PR10348 and BBS/E/F/000PR10352). A.P. and T.R.C. acknowledge support from Supercomputing Wales, which is partially funded by the European Regional Development Fund (ERDF) via Welsh Government. The project was also supported by specific funding from Welsh Government, which provided funds for the sequencing and analysis of a subset of the Welsh samples used in this study, via Genomics Partnership Wales. Conceptualization, E.V. N.J.L. A.R. and T.R.C.; Data Generation, S.M.R. J. Shepherd, R.S. K.L. N.P. M.B. D.L.R. E.C.T. and COG-UK; Methodology, E.V. J. Southgate, D.J.P. R.S. K.L. R. Jarrett, E.C.T. and A.R.; Software, E.V. S.M.N. M.B. I.S. and A.R.; Analysis, E.V. V.H. J.T.M. A.P. A.O. J. Southgate. S.M.R. J. Shepherd. D.J.P. L.G. O.G.P. E.C.T. A.R. and T.R.C.; Writing ? Original Draft, E.V. V.H. J.T.M. A.P. F.F.N. A.R. and T.R.C.; Writing ? Review & Editing, D.J. B.J. F.F.N. A.d.S.F. N.J. L.G. I.G. N.J.L. O.G.P. D.L.R. and E.C.T.; Visualization, E.V. V.H. A.P. D.J. A.O. R. Johnson, J. Shepherd, and A.R.; Supervision, E.V. N.J.L. D.L.R. E.C.T. A.R. and T.R.C.; Funding Acquisition, E.V. N.J.L. E.C.T. A.R. and T.R.C. The authors declare no competing interests. Publisher Copyright: © 2020 The Author(s)
Uncontrolled Keywords: covid-19,epidemiology,evolution,founder effect,sars-cov-2,spike,biochemistry, genetics and molecular biology(all) ,/dk/atira/pure/subjectarea/asjc/1300
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 24 May 2022 15:01
Last Modified: 29 May 2022 07:32
URI: https://ueaeprints.uea.ac.uk/id/eprint/85101
DOI: 10.1016/j.cell.2020.11.020

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