Neuronal gating of tactile input and sleep in 10-month-old infants at typical and elevated likelihood for autism spectrum disorder

De Laet, Anna ORCID:, Piccardi, Elena Serena, Begum-Ali, Jannath, Charman, Tony, Johnson, Mark H., Jones, Emily J. H., Bedford, Rachael and Gliga, Teodora and the STAARS Team (2022) Neuronal gating of tactile input and sleep in 10-month-old infants at typical and elevated likelihood for autism spectrum disorder. Scientific Reports, 12. ISSN 2045-2322

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Sleep problems in Autism Spectrum Disorder (ASD) emerge early in development, yet the origin remains unclear. Here, we characterise developmental trajectories in sleep onset latency (SOL) and night awakenings in infants at elevated likelihood (EL) for ASD (who have an older sibling with ASD) and infants at typical likelihood (TL) for ASD. Further, we test whether the ability to gate tactile input, using an EEG tactile suppression index (TSI), associates with variation in SOL and night awakenings. Parent-reported night awakenings and SOL from 124 infants (97 at EL for ASD) at 5, 10 and 14 months were analyzed using generalized estimating equations. Compared to TL infants, infants at EL had significantly more awakenings and longer SOL at 10 and 14 months. The TSI predicted SOL concurrently at 10 months, independent of ASD likelihood status, but not longitudinally at 14 months. The TSI did not predict night awakenings concurrently or longitudinally. These results imply that infants at EL for ASD wake up more frequently during the night and take longer to fall asleep from 10 months of age. At 10 months, sensory gating predicts SOL, but not night awakenings, suggesting sensory gating differentially affects neural mechanisms of sleep initiation and maintenance.

Item Type: Article
Additional Information: Data availability: At present, the datasets generated and/or analysed during the currentstudy are not publicly available due to confidentiality constraints within our ethical approvals. In the future, we hope to make these datasets available via The BASIS Network ( upon completion of the requisite data access and sharing protocols. Acknowledgements: This research was supported by the Medical Research Council (MR/K021389/1; MHJ, TC). Further, this work was also supported by the EU-AIMS and AIMS-2-TRIALS programmes funded by the Innovative Medicines Initiative (IMI) Joint Undertaking Grant Nos. 115300 (MHJ, TC) and No. 777394 (MHJ, EJHJ and TC; European Union’s FP7 and Horizon 2020, respectively). This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme, with in-kind contributions from the European Federation of Pharmaceutical Industries and Associations (EFPIA) companies and funding from Autism Speaks, Autistica and SFARI. Teodora Gliga was funded by a Wellcome Trust grant (217469/Z/19/Z), Rachael Bedford by a King’s Prize Fellowship (204823/Z/16/Z), and Elena Serena Piccardi by a Wellcome Trust grant [204770/Z/16/Z]. We would like to warmly thank all the parents/caregivers and infants that took part in this study. The STAARS team consists of: Mary Agyapong, Tessel Bazelmans, Leila Dafner, Mutluhan Ersoy, Amy Goodwin, Rianne Haartsen, Hanna Halkola, Alexandra Hendry, Rebecca Holman, Sarah Kalwarowsky, Anna Kolesnik-Taylor, Sarah Lloyd-Fox, Luke Mason, Nisha Narvekar, Greg Pasco, Laura Pirazzoli and Chloë Taylor.
Faculty \ School: Faculty of Social Sciences > School of Psychology
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Depositing User: LivePure Connector
Date Deposited: 06 May 2022 03:59
Last Modified: 03 Nov 2022 16:35
DOI: 10.1038/s41598-022-18018-w

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