Critical role of maternal selenium nutrition in neurodevelopment: Effects on offspring behavior and neuroinflammatory profile

Ajmone-Cat, Maria Antonietta, De Simone, Roberta, Tartaglione, Anna Maria, Di Biase, Antonella, Di Benedetto, Rita, D'Archivio, Massimo, Varì, Rosaria, Ricceri, Laura, Aureli, Federica, Iacoponi, Francesca, Raggi, Andrea, Cubadda, Francesco, Fairweather-Tait, Susan ORCID:, Calamandrei, Gemma and Minghetti, Luisa (2022) Critical role of maternal selenium nutrition in neurodevelopment: Effects on offspring behavior and neuroinflammatory profile. Nutrients, 14 (9). ISSN 2072-6643

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Research in both animals and humans shows that some nutrients are important in pregnancy and during the first years of life to support brain and cognitive development. Our aim was to evaluate the role of selenium (Se) in supporting brain and behavioral plasticity and maturation. Pregnant and lactating female rats and their offspring up to postnatal day 40 were fed isocaloric diets differing in Se content—i.e., optimal, sub-optimal, and deficient—and neurodevelopmental, neuroinflammatory, and anti-oxidant markers were analyzed. We observed early adverse behavioral changes in juvenile rats only in sub-optimal offspring. In addition, sub-optimal, more than deficient supply, reduced basal glial reactivity in sex dimorphic and brain-area specific fashion. In female offspring, deficient and sub-optimal diets reduced the antioxidant Glutathione peroxidase (GPx) activity in the cortex and in the liver, the latter being the key organ regulating Se metabolism and homeostasis. The finding that the Se sub-optimal was more detrimental than Se deficient diet may suggest that maternal Se deficient diet, leading to a lower Se supply at earlier stages of fetal development, stimulated homeostatic mechanisms in the offspring that were not initiated by Se sub-optimal Se. Our observations demonstrate that even moderate Se deficiency during early life negatively may affect, in a sex-specific manner, optimal brain development.

Item Type: Article
Additional Information: Funding: This research was funded by JPI HDHL-INTIMIC Knowledge Platform on Food, Diet, Intestinal Microbiomics and Human Health, JPI HDHL Joint Funding Action: Nutrition and Cognitive Function (Nutricog)–Selenius.
Uncontrolled Keywords: selenium,perinatal exposure,diet,neuroinflammation,microglia,behavior,oxidative stress,food science,nutrition and dietetics ,/dk/atira/pure/subjectarea/asjc/1100/1106
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
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Depositing User: LivePure Connector
Date Deposited: 28 Apr 2022 10:30
Last Modified: 19 Oct 2023 03:19
DOI: 10.3390/nu14091850

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