Recent advances in nanoparticle‑based targeting tactics for antibacterial photodynamic therapy

Thomas-Moore, Brydie A., Arnau del Valle, Carla, Field, Robert A. and Marin, Maria J. (2022) Recent advances in nanoparticle‑based targeting tactics for antibacterial photodynamic therapy. Photochemical & Photobiological Sciences. ISSN 1474-905X

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Abstract

The rise of antibacterial drug resistance means treatment options are becoming increasingly limited. We must find ways to tackle these hard-to-treat drug-resistant and biofilm infections. With the lack of new antibacterial drugs (such as antibiotics) reaching the clinics, research has switched focus to exploring alternative strategies. One such strategy is antibacterial photodynamic therapy (aPDT), a system that relies on light, oxygen, and a non-toxic dye (photosensitiser) to generate cytotoxic reactive oxygen species. This technique has already been shown capable of handling both drug-resistant and biofilm infections but has limited clinical approval to date, which is in part due to the low bioavailability and selectivity of hydrophobic photosensitisers. Nanotechnology-based techniques have the potential to address the limitations of current aPDT, as already well-documented in anti-cancer PDT. Here, we review recent advances in nanoparticle-based targeting tactics for aPDT.

Item Type: Article
Additional Information: Funding Information: This work was supported by the Faculty of Sciences and School of Chemistry at the University of East Anglia in partnership with Mr and Mrs Whittaker oncology fellowship; and the Norwich Research Park Biotechnology and Biological Sciences Research Council (BBSRC) industrial CASE studentship in partnership with Iceni Glycoscience [reference BB/M016609/1].
Uncontrolled Keywords: antibacterial photodynamic therapy,apdt,bacteria,nanoparticles,targeting,physical and theoretical chemistry,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1600/1606
Faculty \ School: Faculty of Science > School of Chemistry
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Depositing User: LivePure Connector
Date Deposited: 21 Apr 2022 16:30
Last Modified: 11 May 2022 15:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/84719
DOI: 10.1007/s43630-022-00194-3

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