Circulating human serum metabolites derived from the intake of a saffron extract (Safr’Inside™) protect neurons from oxidative stress: Consideration for depressive disorders

Wauquier, Fabien, Boutin-Wittrant, Line, Pourtau, Line, Gaudout, David, Moras, Benjamin, Vignault, Adeline, Monchaux De Oliveira, Camille, Gabaston, Julien, Vaysse, Carole, Bertrand, Karène, Abrous, Hélène, Capuron, Lucile, Castanon, Nathalie, Vauzour, David ORCID: https://orcid.org/0000-0001-5952-8756, Roux, Véronique, Macian, Nicolas, Pickering, Gisèle and Wittrant, Yohann (2022) Circulating human serum metabolites derived from the intake of a saffron extract (Safr’Inside™) protect neurons from oxidative stress: Consideration for depressive disorders. Nutrients, 14 (7). ISSN 2072-6643

[thumbnail of nutrients-14-01511]
Preview
PDF (nutrients-14-01511) - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview

Abstract

Increases in oxidative stress have been reported to play a central role in the vulnerability to depression, and antidepressant drugs may reduce increased oxidative stress in patients. Among the plants exerting anti-inflammatory and anti-oxidant properties, saffron, a spice derived from the flower of Crocus sativus, is also known for its positive effects on depression, potentially through its SSRI-like properties. However, the molecular mechanisms underlying these effects and their health benefits for humans are currently unclear. Using an original ex vivo clinical approach, we demonstrated for the first time that the circulating human metabolites produced following saffron intake (Safr’Inside™ ) protect human neurons from oxidative-stress-induced neurotoxicity by preserving cell viability and increasing BNDF production. In particular, the metabolites significantly stimulated both dopamine and serotonin release. In addition, the saffron’s metabolites were also able to protect serotonergic tone by inhibiting the expression of the serotonin transporter SERT and down-regulating serotonin metabolism. Altogether, these data provide new biochemical insights into the mechanisms underlying the beneficial impact of saffron on neuronal viability and activity in humans, in the context of oxidative stress related to depression.

Item Type: Article
Additional Information: Funding Information: This project was funded by Activ’Inside and supported by Nouvelle Aquitaine Regional Council in the framework of the “SilverPhytoNutrients” project. The contribution of Y.W. was supported by INRAE. The contribution of PIC/CIC (V.R., N.M. and G.P.) was supported by INSERM and University Hospital.
Uncontrolled Keywords: bdnf,brain,clinical trial,crocetin,depression,dopamine,mental health,serotonin,sert,sh-sy5y,food science,nutrition and dietetics,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1100/1106
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 08 Apr 2022 10:30
Last Modified: 23 Oct 2022 03:41
URI: https://ueaeprints.uea.ac.uk/id/eprint/84526
DOI: 10.3390/nu14071511

Actions (login required)

View Item View Item