Starch hydrogels as targeted colonic drug delivery vehicles

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Koev, Todor T. ORCID: https://orcid.org/0000-0002-8218-9753, Harris, Hannah C., Kiamehr, Sara, Khimyak, Yaroslav Z. ORCID: https://orcid.org/0000-0003-0424-4128 and Warren, Frederick J. (2022) Starch hydrogels as targeted colonic drug delivery vehicles. Carbohydrate Polymers, 289. ISSN 0144-8617

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Abstract

Targeted colonic drug delivery systems are needed for the treatment of endemic colorectal pathologies, such as Crohn's disease, ulcerative colitis, and colorectal cancer. These drug delivery vehicles are difficult to formulate, as they need to remain structurally intact whilst navigating a wide range of physiological conditions across the upper gastrointestinal tract. In this work we show how starch hydrogel bulk structural and molecular level parameters influence their properties as drug delivery platforms. The in vitro protocols mimic in vivo conditions, accounting for physiological concentrations of gastrointestinal hydrolytic enzymes and salts. The structural changes starch gels undergo along the entire length of the human gastrointestinal tract have been quantified, and related to the materials' drug release kinetics for three different drug molecules, and interactions with the large intestinal microbiota. It has been demonstrated how one can modify their choice of starch in order to fine tune its corresponding hydrogel's pharmacokinetic profile.

Item Type: Article
Uncontrolled Keywords: sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Science > School of Pharmacy
UEA Research Groups: Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
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Depositing User: LivePure Connector
Date Deposited: 30 Mar 2022 09:30
Last Modified: 27 Nov 2023 02:46
URI: https://ueaeprints.uea.ac.uk/id/eprint/84346
DOI: 10.1016/j.carbpol.2022.119413

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