Thirty years of resistance: Zig-zag through the plant immune system

Ngou, Bruno Pok Man, Ding, Pingtao and Jones, Jonathan D. G. (2022) Thirty years of resistance: Zig-zag through the plant immune system. The Plant Cell, 34 (5). 1447–1478. ISSN 1040-4651

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Understanding the plant immune system is crucial for using genetics to protect crops from diseases. Plants resist pathogens via a two-tiered innate immune detection-and-response system. The first plant Resistance (R) gene was cloned in 1992 (Johal and Briggs, 1992). Since then, many cell-surface pattern recognition receptors (PRRs) have been identified, and R genes that encode intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) have been cloned. Here, we provide a list of characterized PRRs and NLRs. In addition to immune receptors, many components of immune signaling networks were discovered over the last 30 years. We review the signaling pathways, physiological responses, and molecular regulation of both PRR- and NLR-mediated immunity. Recent studies have reinforced the importance of interactions between the two immune systems. We provide an overview of interactions between PRR- and NLR-mediated immunity, highlighting challenges and perspectives for future research.

Item Type: Article
Additional Information: Acknowledgments: We thank Samuel Warner, Shanshan Wang, and Jack Rhodes for discussions and suggestions. We thank the Gatsby Foundation for funding to the J.D.G.J. laboratory. B.P.M.N was supported by the Norwich Research Park Biosciences Doctoral Training Partnership from the Biotechnology and Biological Sciences Research Council (BBSRC) (grant agreement BB/M011216/1); P.D. acknowledges support from the the Future Leader Fellowship from BBSRC (grant agreement BB/R012172/1).
Uncontrolled Keywords: plant science,cell biology ,/dk/atira/pure/subjectarea/asjc/1100/1110
Faculty \ School: Faculty of Science > The Sainsbury Laboratory
Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 22 Feb 2022 11:30
Last Modified: 22 Oct 2022 17:35
DOI: 10.1093/plcell/koac041


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