Identifying the limitations of cardiopulmonary exercise testing prior to esophagectomy using a pooled analysis of patient-level data

Sivakumar, Jonathan, Forshaw, Matthew J., Lam, Stephen ORCID:, Peters, Christopher J., Allum, William H., Whibley, Jessica, Sinclair, Rhona C. F., Snowden, Christopher P., Hii, Michael W., Sivakumar, Harry and Read, Matthew (2022) Identifying the limitations of cardiopulmonary exercise testing prior to esophagectomy using a pooled analysis of patient-level data. Diseases of the Esophagus, 35 (11). ISSN 1120-8694

[thumbnail of Accepted manuscript]
PDF (Accepted manuscript) - Accepted Version
Download (502kB) | Preview


Preoperative cardiopulmonary exercise testing (CPET) provides an objective assessment of aerobic fitness in patients undergoing surgery. While peak oxygen uptake during exercise (VO2peak) and anaerobic threshold have demonstrated a moderate correlation with the development of complications following esophagectomy, no clinically useful threshold values have been defined. By pooling patient level data from existing studies, we aimed to define optimal thresholds for preoperative CPET parameters to predict patients at high risk of postoperative complications. Studies reporting on the relationship between preoperative CPET variables and post-esophagectomy complications were determined from a comprehensive literature search. Patient-level data were obtained from six contributing centers for pooled-analyses. Outcomes of interest included cardiopulmonary and non-cardiopulmonary complications, unplanned intensive care unit readmission, and 90-day and 12-month all-cause mortality. Receiver operating characteristic curves and logistic regression models estimated the predictive value of CPET parameters for each individual outcome of interest. This analysis comprised of 621 patients who underwent CPET prior to esophagectomy during the period from January 2004 to March 2017. For both anaerobic threshold and VO2peak, none of the receiver operating characteristic curves achieved an area under the curve value > 0.66 for the outcomes of interest. The discriminatory ability of CPET for determining high-risk patients was found to be poor in patients undergoing an esophagectomy. CPET may only carry an adjunct role to clinical decision-making.

Item Type: Article
Uncontrolled Keywords: cancer,esophagectomy,esophagus,risk assessment,gastroenterology ,/dk/atira/pure/subjectarea/asjc/2700/2715
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 22 Feb 2022 11:30
Last Modified: 09 Feb 2023 01:38
DOI: 10.1093/dote/doac005


Downloads per month over past year

Actions (login required)

View Item View Item