Interventions to treat pain in paediatric CFS/ME: A systematic review

Ascough, Caitlin, King, Hayley, Serafimova, Teona, Beasant, Lucy, Jackson, Sophie, Baldock, Luke, Pickering, Anthony Edward, Brooks, Jonathan ORCID: https://orcid.org/0000-0003-3335-6209 and Crawley, Esther (2020) Interventions to treat pain in paediatric CFS/ME: A systematic review. BMJ Paediatrics Open, 4 (1). ISSN 2399-9772

[thumbnail of PublishedVersion]
Preview
PDF (PublishedVersion) - Published Version
Available under License Creative Commons Attribution Non-commercial.

Download (540kB) | Preview

Abstract

Background Paediatric chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is common (prevalence 1%-2%). Two-thirds of children experience moderate or severe pain, which is associated with increased fatigue and poorer physical function. However, we do not know if treatment for CFS/ME improves pain. Objective Identify whether specialist treatment of paediatric CFS/ME improves pain. Methods We conducted a detailed search in MEDLINE, EMBASE, PsycINFO and the Cochrane Library. Two researchers independently screened texts published between 1994 and 24 January 2019 with no language restrictions. Inclusion criteria were (1) randomised controlled trials and observational studies; (2) participants aged <19 years with CFS/ME; and (3) measure of pain before and after an intervention. Results Of 1898 papers screened, 26 studies investigated treatment for paediatric CFS/ME, 19 of which did not measure pain at any time point. Only five treatment studies measured pain at baseline and follow-up and were included in this review. None of the interventions were specifically targeted at treating pain. Of the included studies, two showed no improvement in pain scores, one suggested an improvement in one subgroup and two studies identified improvements in pain measures in 'recovered' patients compared with 'non-recovered' patients. Conclusions Despite the prevalence and impact of pain in children with CFS/ME surprisingly few treatment studies measured pain. In those that did measure pain, the treatments used focused on overall management of CFS/ME and we identified no treatments that were targeted specifically at managing pain. There is limited evidence that treatment helps improve pain scores. However, patients who recover appear to have less pain than those who do not recover. More studies are needed to determine if pain in paediatric CFS/ME requires a specific treatment approach, with a particular focus on patients who do not recover following initial treatment. PROSPERO registration number CRD42019117540.

Item Type: Article
Additional Information: Funding Information: Funding This work was supported by the UKFPO Academic Foundation Programme. Competing interests One of the authors of this systematic review (EC) was also an author of one of the included papers. However, to avoid a conflict of interest, EC was not involved in the study selection, data extraction or assessment of risk of bias.
Uncontrolled Keywords: chronic fatigue syndrome,pain,pediatrics, perinatology, and child health ,/dk/atira/pure/subjectarea/asjc/2700/2735
Faculty \ School:
Faculty of Social Sciences > School of Psychology
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 10 Feb 2022 09:30
Last Modified: 22 Oct 2022 17:33
URI: https://ueaeprints.uea.ac.uk/id/eprint/83396
DOI: 10.1136/bmjpo-2019-000617

Actions (login required)

View Item View Item