Vitamin D supplementation and mortality

Schoenmakers, Inez (2022) Vitamin D supplementation and mortality. The Lancet Diabetes & Endocrinology, 10 (2). pp. 88-90. ISSN 2213-8587

[thumbnail of Accepted_Manuscript]
PDF (Accepted_Manuscript) - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (177kB) | Preview


In the Lancet Diabetes & Endocrinology, Rachel Neale and colleagues 1 present their findings from D-Health, a population-based, double-blind, placebo-controlled vitamin D3 intervention trial in older Australian adults (n=21 315). It is the largest study to date to assess the effect of vitamin D supplementation on mortality as the primary outcome. No significant reduction in all-cause mortality or from cancer and cardiovascular disease was found. For cancer mortality, hazard ratio point estimates for intention-to-treat and per-protocol analyses were numerically higher in the intervention group, but 95% CIs were wide and crossed 1. Further analyses showed no effect modification according to predicted vitamin D status, indicated by plasma concentration of 25 hydroxy vitamin D (25[OH]D), and BMI explorative analyses excluding the first 2 years of follow-up found a numerically higher hazard ratio for cancer mortality in the vitamin D treated group, but no significant effect on all-cause mortality.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine
Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 19 Jan 2022 14:30
Last Modified: 22 Oct 2022 17:30
DOI: 10.1016/S2213-8587(22)00002-X


Downloads per month over past year

Actions (login required)

View Item View Item