Genomic diversity of bacteriophages infecting the genus Acinetobacter

Oliveira, Hugo, Domingues, Rita, Evans, Benjamin ORCID:, Sutton, J. Mark, Adriaenssens, Evelien M. and Turner, Dann (2022) Genomic diversity of bacteriophages infecting the genus Acinetobacter. Viruses, 14 (2). ISSN 1999-4915

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The number of sequenced Acinetobacter phage genomes in the International Nucleotide Sequence Database Collaboration has increased significantly in recent years, from 37 in 2017 to a total of 139 as of January 2021 with genome sizes ranging from 31 to 378 kb. Here, we explored the genetic diversity of the Acinetobacter phages using comparative genomics approaches that included assessment of nucleotide similarity, shared gene content, single gene phylogeny, and the network-based classification tool vConTACT2. Phages infecting Acinetobacter sp. are genetically diverse and can be grouped into 8 clusters (subfamilies) and 46 sub-clusters (genera), of which 8 represent genomic singletons (additional genera). We propose the creation of five new subfamilies and suggest a reorganisation of the genus Obolenskvirus. These results provide an updated view of the viruses infecting Acinetobacter species, providing insights into their diversity.

Item Type: Article
Additional Information: Funding: H.O. was funded by the Portuguese Foundation for Science and Technology, grant number UIDB/04469/2020. E.M.A was funded by the UK Biotechnology and Biological Sciences Research Council (BBSRC) Institute Strategic Program grant BB/R012490/1 to the Gut Microbes and Health Research Programme and its constituent projects BBS/E/F/000PR10353 and BBS/E/F/000PR10356.
Uncontrolled Keywords: acinetobacter,bacteriophages,bioinformatics,comparative genomics,phage therapy,infectious diseases,virology ,/dk/atira/pure/subjectarea/asjc/2700/2725
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
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Depositing User: LivePure Connector
Date Deposited: 19 Jan 2022 09:30
Last Modified: 19 Oct 2023 03:13
DOI: 10.3390/v14020181


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