Peripheral reaching in Alzheimer's disease and mild cognitive impairment

Mitchell, Alexandra G., Rossit, Stephanie, Pal, Suvankar, Hornberger, Michael, Warman, Annie, Kenning, Elise, Williamson, Laura, Shapland, Rebecca and McIntosh, Robert D. (2022) Peripheral reaching in Alzheimer's disease and mild cognitive impairment. Cortex, 149. pp. 29-43. ISSN 0010-9452

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Abstract

Recent evidence has implicated areas within the posterior parietal cortex (PPC) as among the first to show pathophysiological changes in Alzheimer's disease (AD). Focal brain damage to the PPC can cause optic ataxia, a specific deficit in reaching to peripheral targets. The present study describes a novel investigation of peripheral reaching ability in AD and mild cognitive impairment (MCI), to assess whether this deficit is common among these patient groups. Individuals with a diagnosis of mild-to-moderate AD, or MCI, and healthy older adult controls were required to reach to targets presented in central vision or in peripheral vision using two reaching tasks; one in the lateral plane and another presented in radial depth. Pre-registered case–control comparisons identified 1/10 MCI and 3/17 AD patients with significant peripheral reaching deficits at the individual level, but group-level comparisons did not find significantly higher peripheral reaching error in either AD or MCI by comparison to controls. Exploratory analyses showed significantly increased reach duration in both AD and MCI groups relative to controls, accounted for by an extended Deceleration Time of the reach movement. These findings suggest that peripheral reaching deficits like those observed in optic ataxia are not a common feature of AD. However, we show that cognitive decline is associated with a generalised slowing of movement which may indicate a visuomotor deficit in reach planning or online guidance.

Item Type: Article
Additional Information: This work was funded by the Dunhill Medical Trust Research Project Grant awarded to RDM, SR, SP & MH (RPGF1810∖86). The study in this article earned an Open Data, Open Materials and Preregistered badges for transparent practices. Data and Materials for this study can be found at: https://osf.io/bxnqs.
Uncontrolled Keywords: alzheimer's disease,cognitive impairment,optic ataxia,reaching,visuomotor,neuropsychology and physiological psychology,experimental and cognitive psychology,cognitive neuroscience ,/dk/atira/pure/subjectarea/asjc/3200/3206
Faculty \ School: Faculty of Social Sciences > School of Psychology
Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 13 Jan 2022 09:30
Last Modified: 24 May 2022 14:46
URI: https://ueaeprints.uea.ac.uk/id/eprint/83000
DOI: 10.1016/j.cortex.2022.01.003

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