The use of corticosteroids for choroidal neovascularisation in young patients

Flaxel, Christina J., Owens, Sarah L., Mulholland, Bridget, Schwartz, Steven D. and Gregor, Zdenek J. (1998) The use of corticosteroids for choroidal neovascularisation in young patients. Eye, 12. pp. 266-272. ISSN 0950-222X

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Purpose To investigate the role of systemic corticosteroids in the treatment of sight-threatening choroidal neovascularisation (CNV) in patients with punctate inner choroidopathy (PIC) and multifocal inner choroiditis (MIC). Methods Twelve eyes of 10 patients with evidence of PIC or MIC with recent visual symptoms were identified. All eyes had CNV within the foveal avascular zone on fundus fluorescein angiography (FFA). Systemic oral prednisolone at an initial dose of 1 mg/kg (60-80 mg) was given for 3-5 days and the dose was subsequently tapered. Changes in best corrected visual acuity and leakage on FFA were recorded during follow-up. Systemic side-effects of the corticosteroids were monitored. Results In 10 of 12 eyes vision improved or stabilised. Leakage on FFA resolved in 9 eyes and was reduced in 3. Four patients required more than one course of oral corticosteroids. One patient tvas maintained on low-dose oral corticosteroids for recurrent CNV activity. No systemic complications from the treatment were observed. Conclusion A course of oral corticosteroids in healthy young patients with subfoveal CNV in PIC or MIC may reduce subretinal vascular leakage and stabilise vision when no other proven treatment option is available.

Item Type: Article
Uncontrolled Keywords: choroidal neovascularisation (cnv),chorioretinal scarring,punctate inner choroidopathy (pic),multifocal inner choroiditis (mic),corticosteroid therapy,progressive subretinal fibrosis,disciform macular degeneration,punctate inner choroidopathy,multifocal choroiditis,ocular histoplasmosis,visual prognosis,subfoveal,membranes,steroids,interferon
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 10 Jan 2022 12:30
Last Modified: 23 Oct 2022 03:28
DOI: 10.1038/eye.1998.62

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