Intraocular penetration of tamoxifen

Flaxel, Christina J., Mulholland, Bridget, Haynes, Benjamin and Gregor, Zdenek J. (2000) Intraocular penetration of tamoxifen. Ophthalmology, 107 (11). pp. 2006-2009. ISSN 0014-4169

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Abstract

Objectives: To document ocular penetration of oral tamoxifen in patients being administered systemic therapy by measuring intraocular and serum levels of the drug in a series of patients undergoing elective ocular surgery. Designs: Nonrandomized, prospective, comparative trial. Participants: Twenty-one eyes of 21 patients undergoing elective ocular surgery (cataract extraction or vitrectomy). Twenty patients were using the antiestrogen, tamoxifen, and one participant was not. Nine patients were excluded in the final analysis because of inadequate sample size. Interventions: Preoperative serum samples and perioperative aqueous samples, vitreous samples, or both were obtained for each patient, and these were analyzed for tamoxifen and its metabolites. Dilated fundus examination was performed before surgery on all patients. Main Outcome Measures: Evidence of tamoxifen, its metabolites, or both in the samples. Results: Tamoxifen was detected in all analyzed serum samples (range, 82.4-290.0 ng/ml.) from patients taking the medication and was found to have penetrated into both vitreous (range, 0.5-7.8 ng/ml) and aqueous (range, 0.5-3.9 ng/ml) cavities. No relationship was found between serum and intraocular levels. Conclusions: This study shows that tamoxifen penetrates intraocular fluids to varying degrees. The drug levels in aqueous and vitreous do not appear to correlate with serum levels, Evidence of tamoxifen retinopathy or keratopathy was not seen. Ophthalmology 2000;107:2006-2009 (C) 2000 by the American Academy of Ophthalmology.

Item Type:	Article
Uncontrolled Keywords:	primary breast-cancer,ocular toxicity,n-desmethyltamoxifen,low dosage,long-term,retinopathy,therapy,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	LivePure Connector
Date Deposited:	10 Jan 2022 11:30
Last Modified:	23 Oct 2022 03:28
URI:	https://ueaeprints.uea.ac.uk/id/eprint/82930
DOI:	10.1016/S0161-6420(00)00364-X

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