Synthesis and evaluation of antibacterial and trypanocidal activity of derivatives of monensin A

Jędrzejczyk, Marta, Stępczyńska, Natalia, Klejborowska, Greta, Podsiad, Małgorzata, Stefańska, Joanna, Steverding, Dietmar and Huczyński, Adam (2022) Synthesis and evaluation of antibacterial and trypanocidal activity of derivatives of monensin A. Bioorganic & Medicinal Chemistry Letters, 58. ISSN 0960-894X

[thumbnail of Accepted_Mnauscript]
PDF (Accepted_Mnauscript) - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (832kB) | Preview


The synthesis and biological evaluation of eleven derivatives of the natural polyether ionophore monensin A (MON), modified at the C-26 position, is presented. Eight urethane and three ester derivatives were tested for their antimicrobial activity against different strains of Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa. In addition, their antiparasitic activity was also evaluated with bloodstream forms of Trypanosoma brucei. The majority of the modified ionophores were active against a variety of Gram-positive bacterial strains, including methicillin-resistant S. epidermidis, and showed better antibacterial activity than the unmodified MON. The phenyl urethane derivative of MON exhibited the most promising antibacterial activity of all tested compounds, with minimal inhibitory concentration values of 0.25-0.50 μg/ml. In contrast, none of the MON derivatives displayed higher antitrypanosomal activity than the unmodified ionophore.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 05 Jan 2022 12:31
Last Modified: 27 Dec 2022 01:38
DOI: 10.1016/j.bmcl.2021.128521


Downloads per month over past year

Actions (login required)

View Item View Item