Clinical and endoscopic characteristics associated with post-endoscopy upper gastrointestinal cancers: A systematic review and meta-analysis

Alexandre, Leo, Tsilegeridis-Legeris, Theo and Lam, Stephen (2022) Clinical and endoscopic characteristics associated with post-endoscopy upper gastrointestinal cancers: A systematic review and meta-analysis. Gastroenterology, 162 (4). pp. 1123-1135. ISSN 0016-5085

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Abstract

Background & aims: Ten percent of patients with an upper gastrointestinal cancer will have received an esophagogastroduodenoscopy (EGD) within 3 years before diagnosis, termed post-endoscopy upper gastrointestinal cancers (PEUGIC). We aimed to determine the characteristics of PEUGIC, and compare these with detected cancers.  Methods: We searched MEDLINE and Embase from inception for studies comparing the characteristics of PEUGIC and detected upper gastrointestinal cancers, and reported findings at the initial “cancer-negative” endoscopy. We synthesized results using random effects meta-analysis. This review is registered on PROSPERO, CRD42019125780.  Results: A total of 2696 citations were screened and 25 studies were included, comprising 81,184 UGI cancers, of which 7926 were considered PEUGIC. For PEUGIC assessed within 6 to 36 months of a “cancer-negative” EGD, the mean interval was approximately 17 months. Patients with PEUGIC were less likely to present with dysphagia (odds ratio [OR] 0.37) and weight loss (OR 0.58) and were more likely to present with gastroesophageal reflux (OR 2.64) than detected cancers. PEUGICs were more common in women in Western populations (OR 1.30). PEUGICs were typically smaller at diagnosis and associated with less advanced disease staging compared with detected cancers (OR 2.87 for stage 1 vs 2–4). Most EGDs (>75%) were abnormal preceding diagnosis of PEUGIC.  Conclusions: There is a substantial delay in the diagnosis of PEUGIC. They are less likely to present with alarm symptoms than detected cancers. PEUGICs are overall less advanced at diagnosis. Most patients with PEUGIC have abnormalities reported at the preceding “cancer-negative” EGD. The epidemiology of PEUGIC may inform preventive strategy.

Item Type: Article
Additional Information: Funding Information: Stephen Lam, NIHR Clinical Lecturer, is funded by the National Institute for Health Research (NIHR) for this research project. The views expressed in this publication are those of the authors and not necessarily those of the NIHR, NHS, or the UK Department of Health and Social Care.
Uncontrolled Keywords: missed lesions,peec,pegc,quality indicators,gastroenterology,hepatology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2715
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 04 Jan 2022 10:30
Last Modified: 23 Jun 2022 13:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/82853
DOI: 10.1053/j.gastro.2021.12.270

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