Fosfomycin trometamol for the prevention of infectious complications after prostate biopsy: A consensus statement by an international multidisciplinary group

Bjerklund-Johansen, Truls Erik, Kulchavenya, Ekaterina, Lentz, Gretchen, Livermore, David, Nickel, J. Curtis, Zhanel, George G. and Bonkat, Gernot (2021) Fosfomycin trometamol for the prevention of infectious complications after prostate biopsy: A consensus statement by an international multidisciplinary group. European Urology Focus. ISSN 2405-4569

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Abstract

Context: Transrectal ultrasound-guided prostate biopsy (TRPB) has been a standard of care for diagnosing prostate cancer but is associated with a high incidence of infectious complications. Objective: To achieve an expert consensus on whether fosfomycin trometamol provides adequate prophylaxis in TRPB and discuss its role as prophylaxis in transperineal prostate biopsy (TPPB). Evidence acquisition: An international multidisciplinary group of experts convened remotely to discuss how to best use fosfomycin in various clinical settings and patient situations. Six statements related to prostate biopsy and the role of fosfomycin were developed, based on literature searches and relevant clinical experience. Evidence synthesis: Consensus was reached for all six statements. The group of experts was unanimous regarding fosfomycin as a preferred candidate for antimicrobial prophylaxis in TRPB. Fosfomycin potentially also meets the requirements for empiric prophylaxis in TPPB, although further clinical studies are needed to confirm or refute its utility in this setting. There is a risk of bias due to sponsorship by a pharmaceutical company. Conclusions: Antimicrobial prophylaxis is mandatory in TRPB, and fosfomycin trometamol is an appropriate candidate due to low rates of resistance, a good safety profile, sufficient prostate concentrations, and demonstrated efficacy in reducing the risk of infectious complications following TRPB. Patient summary: Patients undergoing transrectal ultrasound-guided prostate biopsy (TRPB) have a high risk of infectious complications, and antimicrobial prophylaxis is mandatory. However, increasing antimicrobial resistance, as well as safety concerns with fluoroquinolones, has restricted the number of antimicrobial options. Fosfomycin trometamol meets the requirements for a preferred antimicrobial in the prophylaxis of TRPB.

Item Type: Article
Uncontrolled Keywords: antimicrobial prophylaxis,fosfomycin trometamol,infectious complications,transperineal prostate biopsy,transrectal prostate biopsy,urology ,/dk/atira/pure/subjectarea/asjc/2700/2748
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 17 Dec 2021 07:30
Last Modified: 04 Jan 2022 16:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/82718
DOI: 10.1016/j.euf.2021.11.007

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