Impact of changed co-amoxiclav susceptibility testing formats on apparent resistance rates for bloodstream Escherichia coli in a long-term surveillance

Reynolds, Rosy, Mushtaq, Shazad, Allen, Michael K., Horner, Carolyne, Longshaw, Christopher and Livermore, David M. (2022) Impact of changed co-amoxiclav susceptibility testing formats on apparent resistance rates for bloodstream Escherichia coli in a long-term surveillance. Journal of Antimicrobial Chemotherapy, 77 (4). 1206–1208. ISSN 0305-7453

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Abstract

Until 2014 the BSAC advocated that co-amoxiclav MICs should be determined using a 2:1 gravimetric ratio of amoxicillin and clavulanate. Subsequently, following adoption of EUCAST breakpoints, this advice changed to using clavulanate at a fixed concentration of 2 mg/L. The effect was to lower the breakpoint for Enterobacterales from systemic infections from 8 + 4 to 8 + 2 mg/L. We report on the consequences for apparent resistance prevalence among Escherichia coli as recorded in the BSAC Bacteraemia Antimicrobial Resistance Surveillance Programme.

Item Type: Article
Additional Information: Funding information: The BSAC Antimicrobial Resistance Surveillance Programme was wholly supported by the pharmaceutical industry. A list of companies that provided sponsorship throughout the Surveillance Programme is available at http://www.bsacsurv.org. R.R. acknowledges grant support from the BSAC to finance analysis of accumulated data from its Surveillance Programmes, as well as support from the NIHR Health Protection Research Unit in Behavioural Science and Evaluation at the University of Bristol.
Uncontrolled Keywords: pharmacology,microbiology (medical),infectious diseases,pharmacology (medical) ,/dk/atira/pure/subjectarea/asjc/3000/3004
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 04 Dec 2021 01:42
Last Modified: 24 May 2022 14:43
URI: https://ueaeprints.uea.ac.uk/id/eprint/82557
DOI: 10.1093/jac/dkab483

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