Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin

Garg, Pankaj, Morris, Paul, Fazlanie, Asma Lina, Vijayan, Sethumadhavan, Dancso, Balazs, Dastidar, Amardeep Ghosh, Plein, Sven, Mueller, Christian and Haaf, Philip (2017) Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin. Internal and Emergency Medicine, 12 (2). pp. 147-155. ISSN 1828-0447

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Abstract

The role of cardiac troponins as diagnostic biomarkers of myocardial injury in the context of acute coronary syndrome (ACS) is well established. Since the initial 1st-generation assays, 5th-generation high-sensitivity cardiac troponin (hs-cTn) assays have been developed, and are now widely used. However, its clinical adoption preceded guidelines and even best practice evidence. This review summarizes the history of cardiac biomarkers with particular emphasis on hs-cTn. We aim to provide insights into using hs-cTn as a quantitative marker of cardiomyocyte injury to help in the differential diagnosis of coronary versus non-coronary cardiac diseases. We also review the recent evidence and guidelines of using hs-cTn in suspected ACS.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 24 Nov 2021 03:16
Last Modified: 02 Dec 2021 02:49
URI: https://ueaeprints.uea.ac.uk/id/eprint/82309
DOI: 10.1007/s11739-017-1612-1

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