Clinical applications of intra-cardiac four-dimensional flow cardiovascular magnetic resonance: A systematic review

Crandon, Saul, Elbaz, Mohammed S.M., Westenberg, Jos J.M., Geest, Rob J. van der, Plein, Sven and Garg, Pankaj (2017) Clinical applications of intra-cardiac four-dimensional flow cardiovascular magnetic resonance: A systematic review. International Journal of Cardiology, 249. pp. 486-493. ISSN 1874-1754

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Abstract

Background Four-dimensional flow cardiovascular magnetic resonance (4D flow CMR) is an emerging non-invasive imaging technology used to visualise and quantify intra-cardiac blood flow. The aim of this systematic review is to assess the literature on the current clinical applications of intra-cardiac 4D flow CMR. Methods A systematic review was conducted to evaluate the literature on the intra-cardiac clinical applications of 4D flow CMR. Structured searches were carried out on Medline, EMBASE and the Cochrane Library in October 2016. A modified Critical Skills Appraisal Programme (CASP) tool was used to objectively assess and score the included studies. Studies were categorised as ‘highly clinically applicable’ for scores of 67–100%, ‘potentially clinically applicable’ for 34–66% and ‘less clinically applicable’ for 0–33%. Results Of the 1608 articles screened, 44 studies met eligibility for systematic review. The included literature consisted of 22 (50%) mechanistic studies, 18 (40.9%) pilot studies and 4 (9.1%) diagnostic studies. Based on the modified CASP tool, 27 (62%) studies were ‘highly clinically applicable’, 9 (20%) were ‘potentially clinically applicable’ and 8 (18%) were ‘less clinically applicable’. Conclusions There are many proposed methods for using 4D flow CMR to quantify intra-cardiac flow. The evidence base is mainly mechanistic, featuring single-centred designs. Larger, multi-centre studies are required to validate the proposed techniques and investigate the clinical advantages that 4D flow CMR offers over standard practices.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 23 Nov 2021 01:40
Last Modified: 24 Nov 2021 03:15
URI: https://ueaeprints.uea.ac.uk/id/eprint/82275
DOI: 10.1016/j.ijcard.2017.07.023

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