Factors associated with the development, progression, and outcome of Dupuytren disease treatment: A systematic review

Geoghegan, Luke, Man, Julian, Jain, Abhilash, Price, Andrew, Gibbons, Elizabeth, Jerosch-Herold, Christina ORCID: https://orcid.org/0000-0003-0525-1282, Sidey-Gibbons, Chris and Rodrigues, Jeremy (2021) Factors associated with the development, progression, and outcome of Dupuytren disease treatment: A systematic review. Plastic and Reconstructive Surgery, 148 (5). 753E-763E. ISSN 0032-1052

[thumbnail of final accepted manuscript]
PDF (final accepted manuscript) - Accepted Version
Available under License Unspecified licence.

Download (2MB) | Preview


Background: The factors typically considered to be associated with Dupuytren disease have been described, such as those in the "Dupuytren diathesis." However, the quality of studies describing them has not been appraised. This systematic review aimed to analyze the evidence for all factors investigated for potential association with the development, progression, outcome of treatment, or recurrence of Dupuytren disease. Methods: A systematic review of the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, and Cumulative Index to Nursing and Allied Health Literature databases was conducted using a Preferred Reporting Items for Systematic Reviews and Meta-Analyses-compliant methodology up to September of 2019. Articles were screened in duplicate. Prognostic studies were quality assessed using the Quality in Prognosis Study tool. Results: This study identified 2301 records; 51 met full inclusion criteria reporting data related to 54,491 patients with Dupuytren disease. In total, 46 candidate factors associated with the development of Dupuytren disease were identified. There was inconsistent evidence between the association of Dupuytren disease and the presence of "classic" diathesis factors. The quality of included studies varied, and the generalizability of studies was low. There was little evidence describing the factors associated with functional outcome. Conclusions: This systematic review challenges conventional notions of diathesis factors. Traditional diathesis factors are associated with disease development and recurrence, although they are not significantly associated with poor outcome following intervention based on the current evidence.

Item Type: Article
Additional Information: Funding Information: The Intercalated Bachelor of Science Degree in Surgery Award was awarded to Julian Man, B.Sc., by the Royal College of Surgeons for the specific conduct of this study. Jeremy N. Rodrigues, F.R.C.S., Ph.D., is funded by a National Institute for Health Research Postdoctoral Fellowship (PDF-2017-10-075). This article presents independent research funded by the National Institute for Health Research. The views expressed are those of the authors and not necessarily those of the National Health Service, the National Institute for Health Research, or the Department of Health and Social Care. The authors would like to thank Jacqueline Cousins for expert assistance in the development of our search strategy. Publisher Copyright: © 2021 Lippincott Williams and Wilkins. All rights reserved.
Uncontrolled Keywords: surgery ,/dk/atira/pure/subjectarea/asjc/2700/2746
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Rehabilitation
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 18 Nov 2021 01:54
Last Modified: 15 May 2023 00:37
URI: https://ueaeprints.uea.ac.uk/id/eprint/82157
DOI: 10.1097/PRS.0000000000008420


Downloads per month over past year

Actions (login required)

View Item View Item