Myocardial T1-mapping and extracellular volume in pulmonary arterial hypertension: A systematic review and meta-analysis

Alabed, Samer, Saunders, Laura, Garg, Pankaj ORCID: https://orcid.org/0000-0002-5483-169X, Shahin, Yousef, Alandejani, Faisal, Rolf, Andreas, Puntmann, Valentina O., Nagel, Eike, Wild, Jim M., Kiely, David G. and Swift, Andrew J. (2021) Myocardial T1-mapping and extracellular volume in pulmonary arterial hypertension: A systematic review and meta-analysis. Magnetic Resonance Imaging, 79. pp. 66-75. ISSN 0730-725X

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Abstract

Introduction: Elevated myocardial T 1-mapping and extracellular volume (ECV) measured on cardiac MR (CMR) imaging is associated with myocardial abnormalities such as oedema or fibrosis. This meta-analysis aims to provide a summary of T 1-mapping and ECV values in pulmonary arterial hypertension (PAH) and compare their values with controls. Methods: We searched CENTRAL, MEDLINE, Embase, and Web of Science in August 2020. We included CMR studies reporting T 1-mapping or ECV values in adults with any type of PAH. We calculated the mean difference of T 1-values and ECV between PAH and controls. Results: We included 12 studies with 674 participants. T 1-values were significantly higher in PAH with the highest mean difference (MD) recorded at the RV insertion points (RVIP) (108 milliseconds (ms), 95% confidence intervals (CI) 89 to 128), followed by the RV free wall (MD 91 ms, 95% CI 56 to 126). The pooled mean T 1-value in PAH at the RVIP was 1084, 95% CI (1071 to 1097) measured using 1.5 Tesla Siemens systems. ECV was also higher in PAH with an MD of 7.5%, 95% CI (5.9 to 9.1) at the RV free wall. Conclusion: T 1 mapping values in PAH patients are on average 9% higher than healthy controls when assessed under the same conditions including the same MRI system, magnetic field strength or sequence used for acquisition. The highest T 1 and ECV values are at the RVIP. T 1 mapping and ECV values in PH are higher than the values reported in cardiomyopathies and were associated with poor RV function and RV dilatation.

Item Type: Article
Additional Information: Funding Information: This work was supported by the Wellcome Trust awards ( 215799/Z/19/Z and 205188/Z/16/Z ). Publisher Copyright: © 2021 The Author(s)
Uncontrolled Keywords: cmr,cardiac mri,extracellular volume,meta-analysis,myocardial t mapping,pulmonary hypertension,biophysics,biomedical engineering,radiology nuclear medicine and imaging ,/dk/atira/pure/subjectarea/asjc/1300/1304
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 13 Nov 2021 01:52
Last Modified: 23 Oct 2022 03:17
URI: https://ueaeprints.uea.ac.uk/id/eprint/82095
DOI: 10.1016/j.mri.2021.03.011

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