Structure and stability of symptoms in first episode psychosis: A longitudinal network approach

Griffiths, Siân Lowri, Leighton, Samuel P., Mallikarjun, Pavan Kumar, Blake, Georgina, Everard, Linda, Jones, Peter B., Fowler, David, Hodgekins, Joanne, Amos, Tim, Freemantle, Nick, Sharma, Vimal, Marshall, Max, McCrone, Paul, Singh, Swaran P., Birchwood, Max and Upthegrove, Rachel (2021) Structure and stability of symptoms in first episode psychosis: A longitudinal network approach. Translational Psychiatry, 11. ISSN 2158-3188

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Early psychosis is characterised by heterogeneity in illness trajectories, where outcomes remain poor for many. Understanding psychosis symptoms and their relation to illness outcomes, from a novel network perspective, may help to delineate psychopathology within early psychosis and identify pivotal targets for intervention. Using network modelling in first episode psychosis (FEP), this study aimed to identify: (a) key central and bridge symptoms most influential in symptom networks, and (b) examine the structure and stability of the networks at baseline and 12-month follow-up. Data on 1027 participants with FEP were taken from the National EDEN longitudinal study and used to create regularised partial correlation networks using the ‘EBICglasso’ algorithm for positive, negative, and depressive symptoms at baseline and at 12-months. Centrality and bridge estimations were computed using a permutation-based network comparison test. Depression featured as a central symptom in both the baseline and 12-month networks. Conceptual disorganisation, stereotyped thinking, along with hallucinations and suspiciousness featured as key bridge symptoms across the networks. The network comparison test revealed that the strength and bridge centralities did not differ significantly between the two networks (C = 0.096153; p = 0.22297). However, the network structure and connectedness differed significantly from baseline to follow-up (M = 0.16405, p = <0.0001; S = 0.74536, p = 0.02), with several associations between psychosis and depressive items differing significantly by 12 months. Depressive symptoms, in addition to symptoms of thought disturbance (e.g. conceptual disorganisation and stereotyped thinking), may be examples of important, under-recognized treatment targets in early psychosis, which may have the potential to lead to global symptom improvements and better recovery.

Item Type: Article
Additional Information: The National EDEN study was funded by the National Institute of Health Research (NIHR) under the Programme Grants for Applied Research (RP-PG-0109-10074). Birmingham and Solihull NHS Foundation Trust acted as study sponsor. M.B. and S.P.S are part funded by the National Institute for Health Research through the Applied Research Collaboration West Midlands (ARC-WM). P.B.J. is part funded by the NIHR ARC East of England. G.B. was supported by the University of Birmingham Department of Population Sciences and Humanities. S.P.L. is funded through a Clinical Academic Fellowship from the Chief Scientist Office, Scotland (CAF/19/04).
Uncontrolled Keywords: psychiatry and mental health,cellular and molecular neuroscience,biological psychiatry ,/dk/atira/pure/subjectarea/asjc/2700/2738
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Mental Health
Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
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Depositing User: LivePure Connector
Date Deposited: 13 Nov 2021 01:50
Last Modified: 19 Oct 2023 03:08
DOI: 10.1038/s41398-021-01687-y


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