Neuropsychiatric symptoms in behavioral variant frontotemporal dementia and Alzheimer's disease: A 12-month follow-up study

Da Silva, Thais Bento Lima, Ordonez, Tiago Nascimento, Bregola, Allan Gustavo, Bahia, Valéria Santoro, Cecchini, Mário Amore, Guimarães, Henrique Cerqueira, Gambogi, Leandro Boson, Caramelli, Paulo, Balthazar, Marcio Luiz Figueredo, Damasceno, Benito Pereira, Brucki, Sonia Maria Dozzi, De Souza, Leonardo Cruz, Nitrini, Ricardo and Yassuda, Monica Sanches (2021) Neuropsychiatric symptoms in behavioral variant frontotemporal dementia and Alzheimer's disease: A 12-month follow-up study. Frontiers in Neurology, 12. ISSN 1664-2295

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Abstract

Introduction: Neuropsychiatric symptoms in patients with frontotemporal dementia (FTD) are highly prevalent and may complicate clinical managements. Objective: To test whether the Neuropsychiatry Inventory (NPI) could detect change in neuropsychiatric symptoms and caregiver's distress in patients diagnosed with behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) from baseline to a 12-month follow-up and to investigate possible predictors of change in NPI scores.  Methods: The sample consisted of 31 patients diagnosed with bvFTD and 28 patients with AD and their caregivers. The Mini-Mental State Examination (MMSE), Addenbrooke's Cognitive Examination Revised (ACE-R), the INECO Frontal Screening (IFS), the Frontal Assessment Battery (FAB), the Executive Interview (EXIT-25) and the NPI were applied. Descriptive statistics, Mann-Whitney U test, Wilcoxon test, Chi square (χ 2) test and Linear Regression Analysis were used.  Results: NPI total and caregiver distress scores were statistically higher among bvFTD patients at both assessment points. MMSE, ACE-R scores significantly declined and NPI Total and Distress scores significantly increased in both groups. In the bvFTD group, age was the only independent predictor variable for the NPI total score at follow up. In the AD group, ACE-R and EXIT-25, conjunctively, were associated with the NPI total score at follow up.  Conclusions: In 12 months, cognition declined and neuropsychiatric symptoms increased in bvFTD and AD groups. In the AD group only, cognitive impairment was a significant predictor of change in neuropsychiatric symptoms.

Item Type: Article
Additional Information: Funding Information: This project was supported by the São Paulo Research Foundation (FAPESP) Grant Number: 11/04804-1 and 16/07967-2. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Grant Number: 151684/2014-6 and by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Grant Number: 88881.131619/2016-01.
Uncontrolled Keywords: alzheimer's disease (ad),aging,behavioral dementia frontotemporal (bvftd),elderly,neuropsychiatric symptoms,neurology,clinical neurology ,/dk/atira/pure/subjectarea/asjc/2800/2808
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
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Depositing User: LivePure Connector
Date Deposited: 29 Oct 2021 00:41
Last Modified: 10 Nov 2021 08:15
URI: https://ueaeprints.uea.ac.uk/id/eprint/81925
DOI: 10.3389/fneur.2021.728108

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