The oesophageal microbiome and cancer: Hope or hype?

Kumar, Bhaskar, Lam, Stephen, Adam, Mina, Gilroy, Rachel and Pallen, Mark J. (2021) The oesophageal microbiome and cancer: Hope or hype? Trends in Microbiology. ISSN 0966-842X

[img] PDF (Accepted_Manuscript) - Accepted Version
Restricted to Repository staff only until 4 September 2022.
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (241kB) | Request a copy

Abstract

The human oesophagus is home to a complex microbial community, the oesophageal microbiome. Despite decades of work, we still have only a poor, low-resolution view of this community, which makes it hard to distinguish hope from hype when it comes to assessing links between the oesophageal microbiome and cancer. Here we review the potential importance of this microbiome and discuss new approaches, including culturomics, metagenomics, and recovery of whole-genome sequences, that bring renewed hope for an in-depth characterisation of this community that could deliver translational impact.

Item Type: Article
Additional Information: Funding Information: M.J.P. is supported by the Quadram Institute Bioscience BBSRC-funded Strategic Program: Microbes in the Food Chain (project no. BB/R012504/1 ) and its constituent project BBS/E/F/000PR10351 (Theme 3, Microbial Communities in the Food Chain). Publisher Copyright: © 2021 Elsevier Ltd
Uncontrolled Keywords: barrett's oesophagus,gastro-oesophageal reflux,microbiome,oesophageal adenocarcinoma,oesophageal squamous cell carcinoma,microbiology,microbiology (medical),virology,infectious diseases,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2400/2404
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Biological Sciences
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 29 Oct 2021 00:40
Last Modified: 17 Nov 2021 04:48
URI: https://ueaeprints.uea.ac.uk/id/eprint/81912
DOI: 10.1016/j.tim.2021.08.007

Actions (login required)

View Item View Item