Molecular mechanisms of early plant pattern-triggered immune signaling

DeFalco, Thomas A. and Zipfel, Cyril (2021) Molecular mechanisms of early plant pattern-triggered immune signaling. Molecular Cell, 81 (17). pp. 3449-3467. ISSN 1097-2765

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Abstract

All eukaryotic organisms have evolved sophisticated immune systems to appropriately respond to biotic stresses. In plants and animals, a key part of this immune system is pattern recognition receptors (PRRs). Plant PRRs are cell-surface-localized receptor kinases (RKs) or receptor proteins (RPs) that sense microbe- or self-derived molecular patterns to regulate pattern-triggered immunity (PTI), a robust form of antimicrobial immunity. Remarkable progress has been made in understanding how PRRs perceive their ligands, form active protein complexes, initiate cell signaling, and ultimately coordinate the cellular reprogramming that leads to PTI. Here, we discuss the critical roles of PRR complex formation and phosphorylation in activating PTI signaling, as well as the emerging paradigm in which receptor-like cytoplasmic kinases (RLCKs) act as executors of signaling downstream of PRR activation.

Item Type: Article
Additional Information: Funding Information: The authors thank all of the members of the Zipfel group for helpful discussions and comments. C.Z. acknowledges generous funding to study plant immune signaling by the Gatsby Charitable Foundation , the Biotechnology and Biological Research Council ( BB/P012574/1 ), the European Research Council under the European Union (EU)'s Horizon 2020 research and innovation programme (grant agreements no. 309858 , project “PHOSPHinnATE,” and no. 773153 , project “IMMUNO-PEPTALK”), the University of Zurich , and the Swiss National Science Foundation grant no. 31003A_182625 . T.A.D. was supported by postdoctoral fellowships from the European Molecular Biology Organization (EMBO LTF 100-2017 ) and the Natural Sciences and Engineering Research Council of Canada (NSERC PDF-532561-2019 ). Publisher Copyright: © 2021 Elsevier Inc.
Uncontrolled Keywords: molecular biology,cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1312
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Depositing User: LivePure Connector
Date Deposited: 21 Oct 2021 01:25
Last Modified: 21 Oct 2021 01:25
URI: https://ueaeprints.uea.ac.uk/id/eprint/81842
DOI: 10.1016/j.molcel.2021.07.029

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