Early lowering of blood pressure after acute intracerebral haemorrhage: A systematic review and meta-analysis of individual patient data

Moullaali, Tom J., Wang, Xia, Sandset, Else Charlotte, Woodhouse, Lisa J., Law, Zhe Kang, Arima, Hisatomi, Butcher, Kenneth S., Chalmers, John, Delcourt, Candice, Edwards, Leon, Gupta, Salil, Jiang, Wen, Koch, Sebastian, Potter, John, Qureshi, Adnan I., Robinson, Thompson G., Al-Shahi Salman, Rustam, Saver, Jeffrey L., Sprigg, Nikola, Wardlaw, Joanna M., Anderson, Craig S. and Bath, Philip M. and On behalf of the Blood Pressure in Acute Stroke (BASC) Investigators (2022) Early lowering of blood pressure after acute intracerebral haemorrhage: A systematic review and meta-analysis of individual patient data. Journal of Neurology, Neurosurgery and Psychiatry, 93 (1). pp. 6-13. ISSN 0022-3050

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Objective: To summarise evidence of the effects of blood pressure (BP)-lowering interventions after acute spontaneous intracerebral haemorrhage (ICH). Methods: A pre-specified systematic review of the Cochrane Central Register of Controlled Trials, EMBASE and MEDLINE databases from inception to 23 June 2020 to identify randomised controlled trials that compared active BP-lowering agents vs. placebo or intensive vs. guideline BP-lowering targets for adults <7 days after ICH onset. The primary outcome was function (distribution of scores on the modified Rankin scale) 90 days after randomisation. Radiological outcomes were absolute (>6ml) and proportional (>33%) haematoma growth at 24 hours. Meta-analysis used a one-stage approach, adjusted using generalised linear mixed models with pre-specified covariables and trial as a random effect. Results: Of 7094 studies identified, 50 trials involving 11,494 patients were eligible and 16 (32.0%) shared patient-level data from 6,221 (54.1%) patients (mean age 64.2 [SD 12.9], 2,266 [36.4%] females) with a median time from symptom onset to randomisation of 3.8 hours (IQR 2.6−5.3). Active/intensive BP-lowering interventions had no effect on the primary outcome compared to placebo/guideline treatment (adjusted OR for unfavourable shift in modified Rankin scale scores: 0.97, 95% confidence interval 0.88 to 1.06; p=0.50), but there was significant heterogeneity by strategy (pinteraction=0.031) and agent (pinteraction<0.0001). Active/intensive BP-lowering interventions clearly reduced absolute and relative haematoma growth. Interpretation: Overall, a broad range of interventions to lower BP within 7 days of ICH onset had no overall benefit on functional recovery, despite reducing bleeding. The treatment effect appeared to vary according to strategy and agent.

Item Type: Article
Additional Information: Data availability statement: Data are available in a public, open access repository. Data are available on reasonable request. Requests for sharing of de-identified IPD from individual trials used in these analyses should be directed to the corresponding author of the individual trial. The ATACH-II trial data, including de-identified participant data, are available indefinitely at the National Institute of Neurological Disorders and Stroke data archive (https://www.ninds.nih.gov/). To gain access, requesters will need to sign a data-access agreement.
Uncontrolled Keywords: meta-analysis,stroke,surgery,clinical neurology,psychiatry and mental health ,/dk/atira/pure/subjectarea/asjc/2700/2746
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
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Depositing User: LivePure Connector
Date Deposited: 19 Oct 2021 01:14
Last Modified: 03 Nov 2022 16:34
URI: https://ueaeprints.uea.ac.uk/id/eprint/81758
DOI: 10.1136/jnnp-2021-327195

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