Ageing as “early‐life inertia”: Disentangling life‐history trade‐offs along a lifetime of an individual

Carlsson, Hanne, Ivimey‐Cook, Edward, Duxbury, Elizabeth M. L., Edden, Nathan, Sales, Kris and Maklakov, Alexei A. (2021) Ageing as “early‐life inertia”: Disentangling life‐history trade‐offs along a lifetime of an individual. Evolution Letters, 5 (5). pp. 551-564. ISSN 2056-3744

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Abstract

The theory that ageing evolves because of competitive resource allocation between the soma and the germline has been challenged by studies showing that somatic maintenance can be improved without impairing reproduction. However, it has been suggested that cost-free improvement in somatic maintenance is possible only under a narrow range of benign conditions. Here, we show that experimental downregulation of insulin/IGF-1 signaling (IIS) in C. elegans nematodes, a robustly reproducible life span- and health span-extending treatment, reduces fitness in a complex variable environment when initiated during development but does not reduce fitness when initiated in adulthood. Thus, our results show that the costs and benefits of reduced IIS can be uncoupled when organisms inhabit variable environments, and, therefore, do not provide support for the resource allocation theory. Our findings support the theory that the force of natural selection on gene expression in evolutionarily conserved signaling pathways that shape life-history traits declines after the onset of reproduction resulting in organismal senescence.

Item Type: Article
Uncontrolled Keywords: ageing,antagonistic pleiotropy,life-history evolution,senescence,ecology, evolution, behavior and systematics,genetics ,/dk/atira/pure/subjectarea/asjc/1100/1105
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 17 Sep 2021 01:16
Last Modified: 18 Oct 2021 01:05
URI: https://ueaeprints.uea.ac.uk/id/eprint/81447
DOI: 10.1002/evl3.254

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